COX and LOX eicosanoids modulate platelet activation and procoagulation induced by two murine cancer cells

Involvement of arachidonic acid cyclooxygenase (COX) and lipoxygenase (LOX) metabolites in platelet aggregation and coagulation induced by two varieties of cancer cells of murine transplantable tumors was studied. A lung alveolar carcinoma (LAC) and a fibrosarcoma (FS), induced platelet aggregation...

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Bibliographic Details
Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2000-12, Vol.63 (6), p.377-383
Main Authors: Pasqualini, M.E., Mohn, C.E., Petiti, J.P., Manzo, P., Eynard, A.R.
Format: Article
Language:English
Subjects:
Adenocarcinoma, Bronchiolo-Alveolar - pathology
Adenocarcinoma, Bronchiolo-Alveolar - secretion
Animals
Arachidonic Acids - metabolism
Biological and medical sciences
Blood and lymphatic vessels
Blood Coagulation - drug effects
Cardiology. Vascular system
Coculture Techniques
Cysteine Endopeptidases - chemistry
Cysteine Endopeptidases - secretion
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Eicosanoids - biosynthesis
Eicosanoids - classification
Eicosanoids - physiology
Factor X - physiology
Fibrosarcoma - pathology
Fibrosarcoma - secretion
Iodoacetic Acid - pharmacology
Lipoxygenase - metabolism
Lung Neoplasms - pathology
Lung Neoplasms - secretion
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Neoplasm Proteins
Platelet Activation - drug effects
Prostaglandin-Endoperoxide Synthases - metabolism
Thrombophilia - etiology
Thrombophilia - physiopathology
Trypsin Inhibitor, Kunitz Soybean - pharmacology
Tumor Cells, Cultured - drug effects
Tumor Cells, Cultured - secretion
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Summary:Involvement of arachidonic acid cyclooxygenase (COX) and lipoxygenase (LOX) metabolites in platelet aggregation and coagulation induced by two varieties of cancer cells of murine transplantable tumors was studied. A lung alveolar carcinoma (LAC) and a fibrosarcoma (FS), induced platelet aggregation and plasma coagulation (P
ISSN:0952-3278
1532-2823
DOI:10.1054/plef.2000.0228