Solvation enthalpies as descriptors of structure – in vitro percutaneous permeation relationship of benzoxazinones regioisomers

The aim of this work was to correlate the in vitro human skin permeability, expressed as the permeability coefficient ( K p), and some physicochemical parameters of a new series of benzoxazinones. The in vitro human skin permeability of 14 substances, including regioisomers with CH 3, OH, OCH 3, and...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 2000-08, Vol.55 (8), p.563-568
Main Authors: Minghetti, Paola, Casiraghi, Antonella, Cilurzo, Francesco, Montanari, Luisa, Valmen Monzani, M., Bertolini, Giorgio, Zaliani, Andrea
Format: Article
Language:English
Subjects:
Benzoxazinones
Biological and medical sciences
General pharmacology
Humans
In vitro percutaneous absorption
Isomerism
Medical sciences
Permeability
Pharmacology. Drug treatments
Physicochemical characteristics
Physicochemical properties. Structure-activity relationships
Regioisomer
Skin - metabolism
Solvents
Structure-Activity Relationship
Structure–property relationship
Thermodynamics
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Summary:The aim of this work was to correlate the in vitro human skin permeability, expressed as the permeability coefficient ( K p), and some physicochemical parameters of a new series of benzoxazinones. The in vitro human skin permeability of 14 substances, including regioisomers with CH 3, OH, OCH 3, and Cl groups in different positions on the aromatic ring, was determined. The modified Franz diffusion cell method was used. The K p values were in the range 0.14–8.24 cm/h, showing a strong dependence on the position and type of substituent. Physicochemical descriptors usually referred in literature, such as log P, molecular weight and volume (MV), hydrogen bond donor ( H d) and acceptor activity ( H a), and molecular refractivity were considered, with the addition of solvation enthalpy (ΔΔ H solv). ΔΔ H solv is defined as the difference between formation enthalpies in water and octanol. The algorithm with the best correlation between K p and physicochemical descriptors was calculated, taking into account the differences observed among the regioisomers. The algorithm obtained with ΔΔ H solv had a good correlation ( r 2=0.749, F=16.43, P=0.0005), comparable with the equation, proposed by Potts and Guy, based on MV, H d and H a ( r 2=0.830, F=16.3, P=0.0004).
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(00)00048-3