Comparative Study of Staphylococcus aureus Isolated from Lesional and Non-Lesional Skin of Atopic Dermatitis Patients

The skin of patients with atopic dermatitis (AD) is often colonized by Staphylococcus aureus, and superantigenic exotoxins produced by the organism are thought to be an important precipitating factor of AD. However, there are few reports comparing the characteristics of S. aureus isolated from the l...

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Bibliographic Details
Published in:MICROBIOLOGY and IMMUNOLOGY 2000, Vol.44(11), pp.945-947
Main Authors: Matsui, Katsuhiko, Nishikawa, Akemi, Suto, Hajime, Tsuboi, Ryoji, Ogawa, Hideoki
Format: Article
Language:English
Subjects:
Adolescent
Adult
Atopic dermatitis
Bacterial diseases
Bacterial diseases of the skin
Biological and medical sciences
Child
Colony Count, Microbial
Dermatitis, Atopic - microbiology
Exotoxins - biosynthesis
Female
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Skin - microbiology
Staphylococcus aureus
Staphylococcus aureus - growth & development
Staphylococcus aureus - immunology
Staphylococcus aureus - isolation & purification
Staphylococcus aureus - metabolism
Superantigen
Superantigens - biosynthesis
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Summary:The skin of patients with atopic dermatitis (AD) is often colonized by Staphylococcus aureus, and superantigenic exotoxins produced by the organism are thought to be an important precipitating factor of AD. However, there are few reports comparing the characteristics of S. aureus isolated from the lesional and non-lesional skin of identical AD patients. In this study, therefore, we examined whether the presence of superantigen-producing S. aureus correlates with the formation of eczematous lesion of AD patients. The detection rate of S. aureus on the lesional skin of AD patients was higher than on the non-lesional skin of AD patients. Furthermore, the bacterial cell count of S. aureus on the lesional skin of AD patients was also significantly higher than that of the non-lesional skin of AD patients. However, there was no significant difference between the detection rate of superantigenic exotoxin-producing S. aureus on the lesional and nonlesional skin of AD patients. These results suggest that the number of S. aureus present is more important in the formation of eczematous lesion of AD patients than the presence of superantigenic exotoxin-producing S. aureus strains per se.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.2000.tb02587.x