PROTECTIVE EFFECTS OF MANGANESE AGAINST LIPID PEROXIDATION

The aim of this study was to investigate the effects of chronic, daily, 30-d administration of manganese chloride (MnCl 2 ) to male Sprague-Dawley rats on lipid peroxidation in various tissues. Rats were intraperitoneally injected with MnCl 2 (20 mg/kg) once daily for 30 con secutive days. The Mn ac...

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Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Part A, 2000-12, Vol.61 (7), p.569-577
Main Authors: Chen, Min-Tzu, Sheu, Jenn-Yuan, Lin, Te-Hsien
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Glutathione - metabolism
Lipid Peroxidation - drug effects
Male
Manganese - pharmacokinetics
Manganese - pharmacology
Medical sciences
Metals - metabolism
Metals and various inorganic compounds
Rats
Rats, Sprague-Dawley
Thiobarbituric Acid Reactive Substances - metabolism
Tissue Distribution
Toxicology
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Summary:The aim of this study was to investigate the effects of chronic, daily, 30-d administration of manganese chloride (MnCl 2 ) to male Sprague-Dawley rats on lipid peroxidation in various tissues. Rats were intraperitoneally injected with MnCl 2 (20 mg/kg) once daily for 30 con secutive days. The Mn accumulated in liver, spleen, adrenal glands, heart, kidneys, lung, and testes. This was associated with decreased lipid peroxidation in liver, spleen, and adrenal glands and a decrease in the levels of Fe in these tissues. In a second group of animals, Mn (20 mg/kg/d) and glutathione (GSH, 15 mg/kg/d) were administered ip for 30 d. GSH counteracted the Mn-induced protective fall in lipid peroxidation, but Fe levels remained lower in liver and spleen. Mn decreases lipid peroxidation in certain tissues, which may involve lowering Fe content, but interaction with Fe is not the sole mechanism.
ISSN:1528-7394
0098-4108
1087-2620
2381-3504
DOI:10.1080/00984100050194090