Effects of Growth Hormone Treatment on Red Cell Plasma Membrane Fatty Acid Constituents in Hypopituitary Adults

The effects of replacement with recombinant human GH (hGH) on red cell plasma membrane fatty acid and cholesterol constituents were assessed in nine adult patients with growth hormone deficiency. They were treated with hGH in a dose of 0.125U.kg−1.wk−1 for four weeks and at 0.25 U.kg1.wk−1 thereafte...

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Bibliographic Details
Published in:Scottish medical journal 2000-10, Vol.45 (5), p.133-136
Main Authors: Leese, G.P., Nicoll, D., Jung, R.T., Gallacher, C., Ross, P.
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Body Mass Index
Drug Administration Schedule
Drug Monitoring
Erythrocyte Membrane - chemistry
Erythrocyte Membrane - drug effects
Fatty Acids - analysis
Female
Glycated Hemoglobin A - metabolism
Growth Hormone - deficiency
Growth Hormone - pharmacology
Growth Hormone - therapeutic use
Humans
Hypopituitarism - blood
Hypopituitarism - drug therapy
Hypopituitarism - etiology
Male
Middle Aged
Phospholipids - analysis
Single-Blind Method
Treatment Outcome
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Summary:The effects of replacement with recombinant human GH (hGH) on red cell plasma membrane fatty acid and cholesterol constituents were assessed in nine adult patients with growth hormone deficiency. They were treated with hGH in a dose of 0.125U.kg−1.wk−1 for four weeks and at 0.25 U.kg1.wk−1 thereafter foran overall mean duration 13.5 ±3.9 months (mean ±SD). The relative proportions of the various phospholipid fatty acid constituents and the proportion of cholesterol in the phospholipid bilayer were assayed every six months. At the end of the study, the percentage of arachadonic acid (20:4) in membrane phospholipid was found to rise by an average of 3.7% (P
ISSN:0036-9330
2045-6441
DOI:10.1177/003693300004500502