Relation of regional sympathetic denervation and myocardial perfusion disturbance to wall motion impairment in Chagas’ cardiomyopathy

Impairment of sinus node autonomic control and myocardial perfusion disturbances have been described in patients with chronic Chagas’ cardiomyopathy. However, it is not clear how these conditions contribute to myocardial damage. In this investigation, iodine-123 (I-123) meta-iodobenzylguanidine (MIB...

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Published in:	The American journal of cardiology 2000-11, Vol.86 (9), p.975-981
Main Authors:	Simões, Marcus Vinicius, Pintya, Antonio Osvaldo, Bromberg-Marin, Guilherme, Sarabanda, Álvaro Valentin, Antloga, Cleide Marques, Pazin-Filho, Antonio, Maciel, Benedito Carlos, Marin-Neto, José Antonio
Format:	Article
Language:	eng
Subjects:	3-Iodobenzylguanidine Adult Analysis of Variance Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular disease Chagas Cardiomyopathy - complications Chagas Cardiomyopathy - diagnostic imaging Chagas Cardiomyopathy - mortality Female Heart Heart - innervation Humans Male Medical sciences Middle Aged Myocardial Contraction Myocarditis. Cardiomyopathies Neurons Probability Radionuclide Imaging Reference Values Regional Blood Flow Sensitivity and Specificity Statistics, Nonparametric Sympathectomy Sympathetic Nervous System - physiology Thallium Radioisotopes Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - mortality
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Summary:	Impairment of sinus node autonomic control and myocardial perfusion disturbances have been described in patients with chronic Chagas’ cardiomyopathy. However, it is not clear how these conditions contribute to myocardial damage. In this investigation, iodine-123 (I-123) meta-iodobenzylguanidine (MIBG) and thallium-201 myocardium segmental uptake were studied in correlation with the severity of left ventricular (LV) dysfunction detected in various phases of Chagas’ heart disease. Group I consisted of 12 subjects (43 ± 4 years, 7 men) with no symptoms and no cardiac involvement on electrocardiogram (ECG) or echocardiography; group II consisted of 13 patients (48 ± 3 years, 9 men) with abnormal resting ECG and/or echocardiographic segmental abnormalities, and LV ejection fraction of ≥0.5; group III was comprised of 12 patients (59 ± 3 years, 10 men) with more severe heart disease, LV dilation, and LV ejection fraction of
ISSN:	0002-9149 1879-1913