Effect of concomitant digoxin and carvedilol therapy on mortality and morbidity in patients with chronic heart failure

We retrospectively performed stepwise logistic regression analysis on 1,509 patients with chronic heart failure in 4 multicenter United States studies and 1 Australia-New Zealand study to examine the effect of digoxin in patients randomized to carvedilol or placebo. Patients receiving digoxin had mo...

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Bibliographic Details
Published in:The American journal of cardiology 2000-11, Vol.86 (9), p.1032-1035
Main Authors: Eichhorn, Eric J, Lukas, Mary Ann, Wu, Boll, Shusterman, Neil
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - administration & dosage
Aged
Biological and medical sciences
Carbazoles - administration & dosage
Cardiotonic agents
Cardiovascular system
Carvedilol
Chronic Disease
Confidence Intervals
Digoxin - administration & dosage
Drug Therapy, Combination
Female
Heart Failure - drug therapy
Heart Failure - mortality
Heart Failure - physiopathology
Humans
Male
Medical sciences
Middle Aged
Morbidity - trends
Pharmacology. Drug treatments
Probability
Propanolamines - administration & dosage
Proportional Hazards Models
Retrospective Studies
Survival Analysis
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Summary:We retrospectively performed stepwise logistic regression analysis on 1,509 patients with chronic heart failure in 4 multicenter United States studies and 1 Australia-New Zealand study to examine the effect of digoxin in patients randomized to carvedilol or placebo. Patients receiving digoxin had more advanced heart failure, the incidence of hospitalization for any cause and the combination of all-cause death and all-cause hospitalization were the same in the digoxin versus no-digoxin groups.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(00)01146-2