Salmonella-Specific Antibodies in Reactive Arthritis

The development and persistence of Salmonella-specific serum antibodies ofdifferent immunoglobulin classes and subclasses were compared between those who developed reactive arthritis (n = 39) and those who did not (n = 58) after Salmonella infection. Antibodies against lipopolysaccharide and SDS-ext...

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Bibliographic Details
Published in:The Journal of infectious diseases 1991-12, Vol.164 (6), p.1141-1148
Main Authors: Mäki-Ikola, Outi, Leirisalo-Repo, Marjatta, Kantele, Anu, Toivanen, Paavo, Granfors, Kaisa
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antibodies
Antibodies, Bacterial - blood
Antigens
Antigens, Bacterial - immunology
Arthritis
Arthritis, Reactive - drug therapy
Arthritis, Reactive - immunology
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Enzyme linked immunosorbent assay
Female
Follow-Up Studies
Human bacterial diseases
Humans
Immunoglobulin A - blood
Immunoglobulin A, Secretory - analysis
Immunoglobulin G - blood
Immunoglobulin M - blood
Infections
Infectious diseases
Lipopolysaccharides - immunology
Male
Medical sciences
Middle Aged
Reactive arthritis
Salmonella
Salmonella - immunology
Salmonella infections
Salmonella Infections - drug therapy
Salmonella Infections - immunology
Yersinia
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Summary:The development and persistence of Salmonella-specific serum antibodies ofdifferent immunoglobulin classes and subclasses were compared between those who developed reactive arthritis (n = 39) and those who did not (n = 58) after Salmonella infection. Antibodies against lipopolysaccharide and SDS-extract antigen were measured by ELISA. A significant difference was seen between the two patient groups after 4–14 months of follow-up; those with reactive arthritis had higher levels of Salmonella-specific IgM, IgG, and IgA class antibodies than those without arthritis. In the increased antibody response, secretory IgA, IgA 1, and IgG2 classes were especially well represented. The persisting antibody response is a common feature in reactive arthritis and supports persistence of the pathogen or its components in the host. The differences observed in antibody profiles between Salmonella- and Yersinia-triggered reactive arthritides suggest certain dissimilarities (e.g., in the location of persisting microbes) in the arthritogenic process due to these two microbes.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/164.6.1141