Metastatic Non-Small Cell Lung Carcinoma With Involvement of Extremity Musculature: Case Report and Review of the Literature

Hematogenous dissemination of non-small cell lung carcinoma (NSCLC) metastatic to skeletal musculature in the absence of osseous involvement is an infrequent occurrence. We retrospectively reviewed our institution's indexed database for patients evaluated from 1975 through 1997 who were diagnos...

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Bibliographic Details
Published in:Mayo Clinic proceedings 2000-12, Vol.75 (12), p.1333-1337
Main Authors: Ramakrishna, Gautam, Harms, Gordon F., Erlichman, Charles
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Non-Small-Cell Lung - pathology
Diagnostic Imaging
Extremities
Female
Humans
Lung Neoplasms - pathology
Male
Medical sciences
Middle Aged
Muscle Neoplasms - secondary
Muscle Neoplasms - therapy
Pneumology
Retrospective Studies
Tumors of the respiratory system and mediastinum
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Summary:Hematogenous dissemination of non-small cell lung carcinoma (NSCLC) metastatic to skeletal musculature in the absence of osseous involvement is an infrequent occurrence. We retrospectively reviewed our institution's indexed database for patients evaluated from 1975 through 1997 who were diagnosed as having skeletal musculature metastases from NSCLC. Eight men and 2 women were identified (age range, 51-80 years at time of metastases). Four primary adenocarcinomas, 4 primary lung squamous cell carcinomas (SCCs), and 2 poorly differentiated primary NSCLCs were identified. Approximate tumor sizes ranged from 10 cm 3 to 288 cm 3. External-beam radiation therapy was used in 7 of 10 cases; complete surgical excision was performed in 3 cases. Patients with known neoplasm who have extremity pain and negative findings on bone scan should be evaluated for soft tissue tumor involvement because such findings significantly affect clinical management. One case of lung SCC metastatic to the quadratus femoris muscle in a 63-year-old man is discussed in detail.
ISSN:0025-6196
1942-5546
DOI:10.4065/75.12.1333