The role of frozen section, gender, age, and tumor size in the differentiation of follicular adenoma from carcinoma: A meta-analysis

Background. The purpose of this study was to reanalyze modern trials and use meta-analysis to determine how well frozen section gender, age, and tumor size could differentiate follicular adenoma from follicular carcinoma. Method. Inclusion criteria were studies where patients had a permanent patholo...

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Published in:Surgery 2000-12, Vol.128 (6), p.1075-1081
Main Authors: Miltenburg, Darlene M., Prost, Henry M., Graviss, Edward A., Arem, Ridha
Format: Article
Language:English
Subjects:
Adenoma - diagnosis
Adenoma - pathology
Adenoma - surgery
Adult
Age Factors
Aged
Carcinoma - diagnosis
Carcinoma - pathology
Carcinoma - surgery
Diagnosis, Differential
Female
Frozen Sections
Humans
Male
Middle Aged
Sex Factors
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Summary:Background. The purpose of this study was to reanalyze modern trials and use meta-analysis to determine how well frozen section gender, age, and tumor size could differentiate follicular adenoma from follicular carcinoma. Method. Inclusion criteria were studies where patients had a permanent pathologic diagnosis of follicular adenoma or follicular carcinoma and underwent frozen section or had clinical features recorded. Data were pooled, and the random effects model of meta-analysis was used. A probability value of less than.05 was considered significant. Results. Nineteen studies were included (n = 3486 patients). Frozen section was evaluated in 11 studies (n = 2204 patients). Frozen section had an 87% sensitivity, a 48% specificity, a 92% and 35% positive and negative predictive value, respectively, an 82% accuracy, an odds ratio of 0.181, a 95% confidence interval (CI) of 0.07 to 0.49, and a probability value of.001. Clinical features were evaluated in 10 studies (n = 1954 patients). Of the patients with follicular carcinoma, 27.5% were male compared with patients with follicular adenoma, of whom 17.7% were male (P
ISSN:0039-6060
1532-7361
DOI:10.1067/msy.2000.109962