New Triene-ansamycins, Thiazinotrienomycins F and G and a Diene-ansamycin, Benzoxazomycin

New triene-ansamycins designated thiazinotrienomycins F (TT-F) and G (TT-G) and a new diene-ansamycin, benzoxazomycin, were isolated from a culture broth of Streptomyces sp. MJ672-m3 and their structures were elucidated by spectroscopic analyses. The Mean Graphs of TT-G suggests that the tumor growt...

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Bibliographic Details
Published in:Journal of antibiotics 2000/09/25, Vol.53(9), pp.886-894
Main Authors: HOSOKAWA, NOBUO, NAGANAWA, HIROSHI, HAMADA, MASA, IINUMA, HIRONOBU, TAKEUCHI, TOMIO, TSUCHIYA, KAYOKO S., HORI, MAKOTO
Format: Article
Language:English
Subjects:
Alanine - analogs & derivatives
Alanine - chemistry
Alanine - isolation & purification
Alanine - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Applied microbiology
benzoxazomycin
Biological and medical sciences
Cell Division - drug effects
Chemotherapic agents
Drug Screening Assays, Antitumor
Fundamental and applied biological sciences. Psychology
HT29 Cells
Humans
Microbiology
Molecular Conformation
Nitroimidazoles - chemistry
Nitroimidazoles - isolation & purification
Nitroimidazoles - pharmacology
Streptomyces
Streptomyces - chemistry
Streptomyces - metabolism
Thiazines - chemistry
Thiazines - isolation & purification
Thiazines - pharmacology
thiazinotrienomycin F
thiazinotrienomycin G
thiazinotrienomycins F
thiazinotrienomycins G
Tumor Cells, Cultured
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Summary:New triene-ansamycins designated thiazinotrienomycins F (TT-F) and G (TT-G) and a new diene-ansamycin, benzoxazomycin, were isolated from a culture broth of Streptomyces sp. MJ672-m3 and their structures were elucidated by spectroscopic analyses. The Mean Graphs of TT-G suggests that the tumor growth inhibitory activities are almost as strong as TT-B, in respect of GI50 and TGI against several human cancer cell lines.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.53.886