Analysis of the distribution of HLA-A alleles in populations from five continents

The variation and frequency of HLA-A genotypes were established by PCR-SSOP typing in diverse geographically distributed populations: Brazilian, Colombian Kogui, Cuban, Mexican, Omani, Singapore Chinese, and South African Zulu. HLA-A allelic families with only one allele were identified for HLA-A∗01...

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Bibliographic Details
Published in:Human immunology 2000-10, Vol.61 (10), p.1048-1052
Main Authors: Middleton, D, Williams, F, Meenagh, A, Daar, A.S, Gorodezky, C, Hammond, M, Nascimento, E, Briceno, I, Perez, M.P
Format: Article
Language:English
Subjects:
Africa
Alleles
Brazil
China
Genetics, Population
Genotype
high resolution DNA typing
histocompatibility locus HLA
Histocompatibility Testing - methods
HLA-A
HLA-A Antigens - classification
HLA-A Antigens - genetics
Humans
Indians, North American
Mexico
Oman
Polymerase Chain Reaction - methods
SSOP
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Summary:The variation and frequency of HLA-A genotypes were established by PCR-SSOP typing in diverse geographically distributed populations: Brazilian, Colombian Kogui, Cuban, Mexican, Omani, Singapore Chinese, and South African Zulu. HLA-A allelic families with only one allele were identified for HLA-A∗01, -A∗23, -A∗25, -A∗31, -A∗32, -A∗36, -A∗43, -A∗69, -A∗80; and with two alleles for HLA-A∗03, -A∗11, -A∗26, -A∗29, -A∗33, -A∗34, and -A∗66. Greater variation was detected for HLA-A∗02, -A∗24, and -A∗68 allele families. Colombian Kogui and Mexican Seris showed the least diversity with respect to HLA-A alleles, albeit with small numbers tested, with only four and five HLA-A alleles identified, respectively. It would appear by their presence in all populations studied, either rural or indigenous, that certain alleles are very important in pathogen peptide presentation.
ISSN:0198-8859
1879-1166
DOI:10.1016/S0198-8859(00)00178-6