Attention deficit hyperactivity disorder : binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment

Involvement of the dopaminergic system has been suggested in patients suffering from attention deficit hyperactivity disorder (ADHD) since the symptoms can be successfully treated with methylphenidate, a potent blocker of the dopamine transporter (DAT). This study reports the findings on the status...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 2000-10, Vol.27 (10), p.1518-1524
Main Authors: DRESEL, S, KRAUSE, J, KRAUSE, K.-H, LAFOUGERE, C, BRINKBÄUMER, K, KUNG, H. F, HAHN, K, TATSCH, K
Format: Article
Language:English
Subjects:
Adult
Attention Deficit Disorder with Hyperactivity - diagnostic imaging
Attention Deficit Disorder with Hyperactivity - drug therapy
Attention Deficit Disorder with Hyperactivity - metabolism
Attention deficit disorders. Hyperactivity
Biological and medical sciences
Brain - diagnostic imaging
Brain - metabolism
Carrier Proteins - metabolism
Caudate Nucleus - diagnostic imaging
Caudate Nucleus - metabolism
Child clinical studies
Corpus Striatum - diagnostic imaging
Corpus Striatum - metabolism
Dopamine - metabolism
Dopamine Plasma Membrane Transport Proteins
Dopamine Uptake Inhibitors - therapeutic use
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Membrane Glycoproteins
Membrane Transport Proteins
Methylphenidate - therapeutic use
Middle Aged
Nerve Tissue Proteins
Nervous system
Organotechnetium Compounds - pharmacokinetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Putamen - diagnostic imaging
Putamen - metabolism
Radionuclide investigations
Radiopharmaceuticals - pharmacokinetics
Tomography, Emission-Computed, Single-Photon
Tropanes - pharmacokinetics
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Summary:Involvement of the dopaminergic system has been suggested in patients suffering from attention deficit hyperactivity disorder (ADHD) since the symptoms can be successfully treated with methylphenidate, a potent blocker of the dopamine transporter (DAT). This study reports the findings on the status of the DAT in adults with ADHD before and after commencement of treatment with methylphenidate, as measured using [99mTc]TRODAT-1. Seventeen patients (seven males, ten females, aged 21-64 years, mean 38 years) were examined before and after the initiation of methylphenidate treatment (3x5 mg/day). All subjects were injected with 800 MBq [99mTc]TRODAT-1 and imaged 3 h p.i. Single-photon emission tomography (SPET) scans were acquired using a triple-headed gamma camera. For semiquantitative evaluation of the DAT, transverse slices corrected for attenuation were used to calculate specific binding in the striatum, with the cerebellum used as background [(STR-BKG)/BKG]. Data were compared with an age-matched control group. It was found that untreated patients presented with a significantly increased specific binding of [99mTc]TRODAT-1 to the DAT as compared with normal controls [(STR-BKG)/BKG: 1.43+/-0.18 vs 1.22+/-0.06, P
ISSN:0340-6997
1619-7070
1619-7089
DOI:10.1007/s002590000330