Properties and functions of diacylglycerol kinases

Diacylglycerol kinases (DGKs) phosphorylate the second-messenger diacylglycerol (DAG) to phosphatidic acid (PA). The family of DGKs is well conserved among most species. Nine mammalian isotypes have been identified, and are classified into five subgroups based on their primary structure. DGKs contai...

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Bibliographic Details
Published in:Cellular Signalling 2000-10, Vol.12 (9), p.595-605
Main Authors: van Blitterswijk, Wim J, Houssa, Brahim
Format: Article
Language:English
Subjects:
Animals
Cytoskeleton
Diacylglycerol
Diacylglycerol kinase
Diacylglycerol Kinase - chemistry
Diacylglycerol Kinase - genetics
Diacylglycerol Kinase - metabolism
Diacylglycerol Kinase - physiology
Humans
Isoenzymes - chemistry
Isoenzymes - genetics
Isoenzymes - metabolism
Isoenzymes - physiology
Nucleus
Phosphatidic acid
Phosphatidylinositol cycle
Protein kinase C
Rho GTPase
Structure-Activity Relationship
Subcellular Fractions
Tissue Distribution
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Summary:Diacylglycerol kinases (DGKs) phosphorylate the second-messenger diacylglycerol (DAG) to phosphatidic acid (PA). The family of DGKs is well conserved among most species. Nine mammalian isotypes have been identified, and are classified into five subgroups based on their primary structure. DGKs contain a conserved catalytic domain and an array of other conserved motifs that are likely to play a role in lipid–protein and protein–protein interactions in various signalling pathways dependent on DAG and/or PA production. DGK is therefore believed to be activated at the (plasma) membrane where DAG is generated. Some isotypes are found associated with and/or regulated by small GTPases of the Rho family, presumably acting in cytoskeletal rearrangements. Others are (also) found in the nucleus, in association with other regulatory enzymes of the phosphoinositide cycle, and have an effect on cell cycle progression. Most DGK isotypes show high expression in the brain, often in distinct brain regions, suggesting that each individual isotype has a unique function.
ISSN:0898-6568
1873-3913
DOI:10.1016/S0898-6568(00)00113-3