Ischemic inactivation of G protein-coupled receptor kinase and altered desensitization of canine cardiac β-adrenergic receptors

G protein-coupled receptor kinases (GRKs) modulate myocardial beta-adrenergic receptor (betaAR) signaling. We examined whether GRK activity was altered 6, 24, and 96 hours after left anterior descending coronary artery ligation (LAD CAL) in the dog. GRK activity was measured in arrhythmogenic subepi...

Full description

Bibliographic Details

Published in:	Circulation (New York, N.Y.) N.Y.), 2000-11, Vol.102 (20), p.2535-2540
Main Authors:	XICHUN YU, MIN ZHANG, KYKER, Kimberly, PATTERSON, Eugene, BENOVIC, Jeffrey L, KEM, David C
Format:	Article
Language:	eng
Subjects:	Adenylyl Cyclases - metabolism Animals beta-Adrenergic Receptor Kinases Binding, Competitive - drug effects Biological and medical sciences Blotting, Western Cardiology. Vascular system Colforsin - pharmacology Coronary heart disease Cyclic AMP-Dependent Protein Kinases - metabolism Disease Models, Animal Dogs Dose-Response Relationship, Drug G-Protein-Coupled Receptor Kinase 5 Heart Isoproterenol - pharmacology Male Medical sciences Myocardial Ischemia - metabolism Myocardial Ischemia - pathology Myocardium - metabolism Myocardium - pathology Protein-Serine-Threonine Kinases - metabolism Radioligand Assay Receptors, Adrenergic, beta - metabolism Signal Transduction - drug effects Sodium-Potassium-Exchanging ATPase - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!