Pedigree Selection and Tests of Linkage in a Hutterite Asthma Pedigree

We explored methods for kinship and linkage analysis in a Hutterite pedigree comprising 1,544 individuals, 72 of whom were diagnosed with asthma. Subpedigrees were selected by (a) identifying nuclear families containing asthmatics, (b) identifying couples with many asthmatic descendants in an ad hoc...

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Bibliographic Details
Published in:Genetic epidemiology 2001, Vol.21 (S1), p.S244-S251
Main Authors: Greenwood, Celia M.T., Bureau, Alexandre, Loredo-Osti, J Concepción, Roslin, Nicole M., Crumley, M. Joyce, Brewer, Carl G., Fujiwara, T. Mary, Goldstein, Darlene R., Morgan, Kenneth
Format: Article
Language:English
Subjects:
Adult
all-shortest-paths pedigree
Asthma - epidemiology
Asthma - genetics
Child
Chromosome Mapping - statistics & numerical data
Chromosomes, Human, Pair 5
condensed identity coefficients
Consanguinity
Female
founder population
Genetic Markers - genetics
Genetics, Population
Humans
identity by descent
Linkage Disequilibrium
Male
Markov chain Monte Carlo
Markov Chains
Monte Carlo Method
nonparametric linkage
Pedigree
South Dakota
transmission/disequilibrium test
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Summary:We explored methods for kinship and linkage analysis in a Hutterite pedigree comprising 1,544 individuals, 72 of whom were diagnosed with asthma. Subpedigrees were selected by (a) identifying nuclear families containing asthmatics, (b) identifying couples with many asthmatic descendants in an ad hoc manner, and (c) finding the most recent common ancestors of all asthmatics. Markov chain Monte Carlo (MCMC) methods were used to estimate allele sharing in the larger subpedigrees and transmission/disequilibrium tests were performed on nuclear families. On chromosome 5q near the cytokine cluster, modest evidence for linkage to asthma was obtained. Using MCMC, we were able to evaluate the evidence for linkage in complex subpedigrees of several hundred individuals, and hence, incorporate some of the co‐ancestry of this founder population. © 2001 Wiley‐Liss, Inc.
ISSN:0741-0395
1098-2272
DOI:10.1002/gepi.2001.21.s1.s244