Left prefrontal activation predicts therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) in major depression

There is evidence that repetitive transcranial magnetic stimulation (rTMS) applied to the prefrontal cortex has antidepressive properties. In the present study we evaluated the clinical status and the hemodynamic responses during mental work in the prefrontal cortex before therapeutic rTMS. Twelve p...

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Bibliographic Details
Published in:Psychiatry research 2000-10, Vol.99 (3), p.161-172
Main Authors: Eschweiler, Gerhard Wilhelm, Wegerer, Christine, Schlotter, Wilfried, Spandl, Christoph, Stevens, Andreas, Bartels, Mathias, Buchkremer, Gerhard
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain Mapping
Cerebrovascular Circulation
Cross-Over Studies
Depressive Disorder, Major - physiopathology
Depressive Disorder, Major - psychology
Depressive Disorder, Major - therapy
Dominance, Cerebral
Electric Stimulation Therapy - methods
Electromagnetic Phenomena
Female
Humans
Major depression
Male
Medical sciences
Middle Aged
Mirror drawing task
Miscellaneous
Near infrared spectroscopy
Prefrontal Cortex - blood supply
Prefrontal Cortex - metabolism
Prognosis
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance
Psychopathology. Psychiatry
Repetitive transcranial magnetic stimulation
Response prediction
Total hemoglobin concentration
Treatment Outcome
Treatments
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Summary:There is evidence that repetitive transcranial magnetic stimulation (rTMS) applied to the prefrontal cortex has antidepressive properties. In the present study we evaluated the clinical status and the hemodynamic responses during mental work in the prefrontal cortex before therapeutic rTMS. Twelve patients diagnosed with major depression (DSM-IV) were randomized in a sham-controlled cross-over treatment protocol of 4 weeks’ duration consisting of two periods of 5 days with rTMS separated by 9 days of no stimulation. rTMS (10 Hz) was applied to the left dorsolateral prefrontal cortex. Hemodynamic changes in the prefrontal cortex during mental work were evaluated by multi-site near-infrared spectroscopy (NIRS). Scores on the Hamilton Depression Rating Scale (HAMD) decreased significantly by −5.4 points after 5 days of active stimulation, whereas it did not change (+1.6 points) after sham stimulation. Absence of a task-related increase of total hemoglobin concentrations at the stimulation site ( P
ISSN:0925-4927
0165-1781
1872-7506
1872-7123
DOI:10.1016/S0925-4927(00)00062-7