Biphasic Decay of Latently Infected CD4+ T Cells in Acute Human Immunodeficiency Virus Type 1 Infection

Latent infection of resting CD4+ T cells represents a major barrier to eradication of human immunodeficiency virus type 1 (HIV-1). The establishment and rate of decay of latent HIV-1 in resting CD+ T cells from 9 acute seroconverters, 7 of whom began to receive highly active antiretroviral therapy (...

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Bibliographic Details
Published in:The Journal of infectious diseases 2000-12, Vol.182 (6), p.1636-1642
Main Authors: Blankson, Joel N., Finzi, Diana, Pierson, Theodore C., Sabundayo, Beulah P., Chadwick, Karen, Margolick, Joseph B., Quinn, Thomas C., Siliciano, Robert F.
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Anti-HIV Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active
Antiretrovirals
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - virology
Cell lines
Cells, Cultured
Disease reservoirs
Half lives
Highly active antiretroviral therapy
HIV 1
HIV Infections - drug therapy
HIV Infections - immunology
HIV Seropositivity - immunology
HIV-1 - physiology
Human viral diseases
Humans
Infections
Infectious diseases
Lymphocyte Count
Major Articles
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
T lymphocytes
Time Factors
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virions
Virus Latency
Viruses
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Summary:Latent infection of resting CD4+ T cells represents a major barrier to eradication of human immunodeficiency virus type 1 (HIV-1). The establishment and rate of decay of latent HIV-1 in resting CD+ T cells from 9 acute seroconverters, 7 of whom began to receive highly active antiretroviral therapy (HAART) shortly after presentation, were studied. Before the initiation of therapy, these patients had very high frequencies of latently infected CD4+ T cells, with a median frequency of 205 infectious units per million resting CD4+ T cells. These values are â©˝ 1 log higher than those seen in chronically infected patients who are not undergoing HAART. The number of latently infected cells declined dramatically after initiation of HAART but then tended to level off at a low but stable level. The biphasic decay of latent HIV in resting CD4+ T cells in acute seroconverters supports current models of pre- and postintegration latency.
ISSN:0022-1899
1537-6613
DOI:10.1086/317615