Loading…
Effects of different serotypes of Escherichia coli lipopolysaccharides on body temperature in rats
The effects of Escherichia coli O55:B5, O127:B8, and O111:B4 serotypes' lipopolysaccharides (LPS) on body temperature were investigated in rats. LPSs were injected intraperitoneally at doses of 2, 50, and 250 μg/kg. A multiphasic and no-dose dependent increase in rectal temperature was observed...
Saved in:
Published in: | Life sciences (1973) 2000-09, Vol.67 (19), p.2319-2329 |
---|---|
Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | The effects of
Escherichia coli O55:B5, O127:B8, and O111:B4 serotypes' lipopolysaccharides (LPS) on body temperature were investigated in rats. LPSs were injected intraperitoneally at doses of 2, 50, and 250 μg/kg. A multiphasic and no-dose dependent increase in rectal temperature was observed in response to
E. coli O55:B5 LPS at all doses, and in response to
E. coli O127:B8 LPS at 2 and 50 μg/kg doses. The highest dose of the latter caused a dual change in rectal temperature, in which hypothermia preceded fever.
E. coli O111:B4 LPS was either pyrogenic or hypothermic at 2 and 250 μg/kg doses; respectively, whereas a dual response was observed when the 50 μg/kg dose was injected. Although dual responses were observed after administration of all LPSs at 50 μg/kg dose when the body temperature was recorded by biotelemetry, the hypothermia induced by
E. coli O55:B5 LPS was significantly smaller. These data suggest that LPSs induce dose and serotype-specific variable changes on body temperature in rats. This variability may be related to the structure of LPSs. The data also indicate that LPS causes hypothermia with or without fever in rats. |
---|---|
ISSN: | 0024-3205 1879-0631 |
DOI: | 10.1016/S0024-3205(00)00821-3 |