Impact of estradiol blood concentrations on skin capillary Laser Doppler flow in premenopausal women

Objective and method: Estradiols are known to prevent cardiovascular diseases, but the underlying mechanisms remain unclear. We assessed the finger skin capillary blood flow in 20 premenopausal women with oral contraception noninvasively by Laser Doppler flowmetry (LDF). Blood flow was registered bo...

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Bibliographic Details
Published in:International journal of cardiology 2000-08, Vol.75 (1), p.59-64
Main Authors: Gerhardt, Ulf, Hillebrand, Uta, Mehrens, Thomas, Hohage, Helge
Format: Article
Language:English
Subjects:
Adult
Autonomic nervous system
Biological and medical sciences
Blood Pressure
Contraceptives, Oral - administration & dosage
Data Interpretation, Statistical
Estradiol
Estradiol - blood
Estradiol - physiology
Female
Fingers - blood supply
Hormones. Endocrine system
Humans
Laser-Doppler Flowmetry
Medical sciences
Microcirculation
Models, Theoretical
Monitoring, Physiologic
Pharmacology. Drug treatments
Premenopause
Regional Blood Flow
Skin - blood supply
Vascular Resistance
Vasodilation
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Summary:Objective and method: Estradiols are known to prevent cardiovascular diseases, but the underlying mechanisms remain unclear. We assessed the finger skin capillary blood flow in 20 premenopausal women with oral contraception noninvasively by Laser Doppler flowmetry (LDF). Blood flow was registered both under basal conditions and after 2 min of arterial occlusion. Furthermore, the combination with a beat-to-beat online finger blood pressure monitor allowed the calculation of the regional peripheral resistance (RPR). All measurements were performed in the menstrual phase. LDF and RPR were correlated to the estradiol whole blood levels. Results: Both baseline ( r 2=0.826; P
ISSN:0167-5273
1874-1754
DOI:10.1016/S0167-5273(00)00292-8