Ras Pathway Specificity Is Determined by the Integration of Multiple Signal-Activated and Tissue-Restricted Transcription Factors

Ras signaling elicits diverse outputs, yet how Ras specificity is generated remains incompletely understood. We demonstrate that Wingless (Wg) and Decapentaplegic (Dpp) confer competence for receptor tyrosine kinase–mediated induction of a subset of Drosophila muscle and cardiac progenitors by actin...

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Bibliographic Details
Published in:Cell 2000-09, Vol.103 (1), p.63-74
Main Authors: Halfon, Marc S, Carmena, Ana, Gisselbrecht, Stephen, Sackerson, Charles M, Jiménez, Fernando, Baylies, Mary K, Michelson, Alan M
Format: Article
Language:English
Subjects:
Animals
Bacterial Proteins
Binding Sites - genetics
Body Patterning - genetics
Cell Lineage - genetics
DNA-Binding Proteins
Drosophila
Drosophila - embryology
Drosophila - genetics
Drosophila - metabolism
Drosophila Proteins
dTCF protein
Enhancer Elements, Genetic - genetics
Eye Proteins - genetics
Eye Proteins - metabolism
Gene Expression Regulation, Developmental - genetics
Heart - embryology
Homeodomain Proteins - genetics
Insect Proteins - genetics
Insect Proteins - metabolism
MAD protein
Mesoderm - metabolism
Muscle, Skeletal - cytology
Muscle, Skeletal - embryology
Muscle, Skeletal - metabolism
Myocardium - cytology
Myocardium - metabolism
Nerve Tissue Proteins
Pointed protein
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
Ras protein
ras Proteins - genetics
ras Proteins - metabolism
Receptor Protein-Tyrosine Kinases - genetics
Receptor Protein-Tyrosine Kinases - metabolism
Repressor Proteins - genetics
Repressor Proteins - metabolism
Signal Transduction - genetics
Stem Cells - cytology
Stem Cells - metabolism
Tinman protein
Transcription Factors - genetics
Twist protein
Wingless protein
Wnt1 Protein
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Summary:Ras signaling elicits diverse outputs, yet how Ras specificity is generated remains incompletely understood. We demonstrate that Wingless (Wg) and Decapentaplegic (Dpp) confer competence for receptor tyrosine kinase–mediated induction of a subset of Drosophila muscle and cardiac progenitors by acting both upstream of and in parallel to Ras. In addition to regulating the expression of proximal Ras pathway components, Wg and Dpp coordinate the direct effects of three signal-activated (dTCF, Mad, and Pointed—functioning in the Wg, Dpp, and Ras/MAPK pathways, respectively) and two tissue-restricted (Twist and Tinman) transcription factors on a progenitor identity gene enhancer. The integration of Pointed with the combinatorial effects of dTCF, Mad, Twist, and Tinman determines inductive Ras signaling specificity in muscle and heart development.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(00)00105-7