Artery and vein separation using susceptibility-dependent phase in contrast-enhanced MRA

In magnetic resonance angiography, contrast agents are frequently used to help highlight arteries over background tissue. Unfortunately, enhancing veins hamper the visualization of arteries when data are collected over a long period of time after the arterial phase of the contrast agent. To overcome...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2000-11, Vol.12 (5), p.661-670
Main Authors: Wang, Y., Yu, Y., Li, D., Bae, K.T., Brown, J.J., Lin, W., Haacke, E.M.
Format: Article
Language:English
Subjects:
Arteries - anatomy & histology
Contrast Media
contrast-enhanced MRA
Dose-Response Relationship, Drug
Gadolinium DTPA
Humans
Image Enhancement
Leg - blood supply
Magnetic Resonance Angiography - methods
Models, Theoretical
MR angiography
Phantoms, Imaging
phase imaging
susceptibility
Veins - anatomy & histology
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Summary:In magnetic resonance angiography, contrast agents are frequently used to help highlight arteries over background tissue. Unfortunately, enhancing veins hamper the visualization of arteries when data are collected over a long period of time after the arterial phase of the contrast agent. To overcome this problem, we have developed a novel imaging and postprocessing method that is capable of eliminating veins by utilizing the susceptibility difference between veins and surrounding tissue. This method was applied in the peripheral vasculature where the vessels are predominantly parallel to the main field and where the blood oxygen level‐dependent effect is most pronounced. Results are presented for both long (15.8 msec) and short echo times (7.8 msec) and for sequential and centrally reordered acquisition schemes. The short echo scan approach appears to be the most promising, making it possible to obtain good suppression of the venous signal even when the timing is not perfect or when repeat scans are necessary. J. Magn. Reson. Imaging 2000;12:661–670. © 2000 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/1522-2586(200011)12:5<661::AID-JMRI2>3.0.CO;2-L