Neural representations of skilled movement

The frontal and parietal cortex are intimately involved in the representation of goal-directed movements, but the crucial neuroanatomical sites are not well established in humans. In order to identify these sites more precisely, we studied stroke patients who had the classic syndrome of ideomotor li...

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Bibliographic Details
Published in:Brain (London, England : 1878) England : 1878), 2000-11, Vol.123 (11), p.2306-2313
Main Authors: Haaland, Kathleen Y., Harrington, Deborah L., Knight, Robert T.
Format: Article
Language:English
Subjects:
Aged
Apraxia, Ideomotor - pathology
Apraxia, Ideomotor - physiopathology
Biological and medical sciences
brain damage
Brain Injuries - complications
Brain Injuries - pathology
Brain Injuries - physiopathology
Cerebral Cortex - blood supply
Cerebral Cortex - pathology
Cerebral Cortex - physiopathology
Extremities - innervation
Extremities - physiopathology
frontal lobes
Humans
limb apraxia
Medical sciences
Middle Aged
Motor Skills - physiology
movement
Movement - physiology
Neural Pathways - pathology
Neural Pathways - physiopathology
Neurology
Neuropsychological Tests
parietal lobes
Psychomotor Performance - physiology
Stroke - complications
Stroke - pathology
Stroke - physiopathology
Vascular diseases and vascular malformations of the nervous system
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Summary:The frontal and parietal cortex are intimately involved in the representation of goal-directed movements, but the crucial neuroanatomical sites are not well established in humans. In order to identify these sites more precisely, we studied stroke patients who had the classic syndrome of ideomotor limb apraxia, which disrupts goal-directed movements, such as writing or brushing teeth. Patients with and without limb apraxia were identified by assessing errors imitating gestures and specifying a cut-off for apraxia relative to a normal control group. We then used MRI or CT for lesion localization and compared areas of overlap in those patients with and without limb apraxia. Patients with ideomotor limb apraxia had damage lateralized to a left hemispheric network involving the middle frontal gyrus and intraparietal sulcus region. Thus, the results revealed that discrete areas in the left hemisphere of humans are critical for control of complex goal-directed movements.
ISSN:0006-8950
1460-2156
DOI:10.1093/brain/123.11.2306