Increased aortic intima-media thickness: A marker of preclinical atherosclerosis in high-risk children

Autopsy studies in children have shown that atherosclerotic lesions begin to develop first in the intima of the aorta. Recent developments in ultrasound techniques have made it possible to visualize the intima-medial thickness of the abdominal aorta directly (aIMT). Therefore, we examined the feasib...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-12, Vol.104 (24), p.2943-2947
Main Authors: JÄRVISALO, Mikko J, JARTTI, Laura, NÄNTÖ-SALONEN, Kirsti, IRJALA, Kerttu, RÖNNEMAA, Tapani, HARTIALA, Jaakko J, CELERMAJER, David S, RAITAKARI, Olli T
Format: Article
Language:English
Subjects:
Adolescent
Aorta, Abdominal - diagnostic imaging
Arteriosclerosis - blood
Arteriosclerosis - diagnosis
Arteriosclerosis - etiology
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - physiology
Cardiology. Vascular system
Child
Cholesterol - blood
Cholesterol, LDL - blood
Diabetes Mellitus, Type 1 - blood
Female
Glycated Hemoglobin A - metabolism
Humans
Hypercholesterolemia - blood
Hyperlipoproteinemia Type II - blood
Lipids - blood
Male
Medical sciences
Multivariate Analysis
Regression Analysis
Reproducibility of Results
Risk Factors
Triglycerides - blood
Tunica Intima - diagnostic imaging
Tunica Media - diagnostic imaging
Ultrasonography - methods
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Summary:Autopsy studies in children have shown that atherosclerotic lesions begin to develop first in the intima of the aorta. Recent developments in ultrasound techniques have made it possible to visualize the intima-medial thickness of the abdominal aorta directly (aIMT). Therefore, we examined the feasibility of measuring aIMT in children and studied its value in distinguishing high-risk children from healthy controls compared with a more established marker of subclinical atherosclerosis, the common carotid artery intima-medial thickness (cIMT). IMTs were measured using high-resolution (13 MHz) ultrasound in 88 children (aged 11+/-2 years); 16 had hypercholesterolemia (LDL cholesterol, 5.1+/-1.2 mmol/L), 44 had type 1 diabetes (mean duration, 4.4+/-3.1 years; LDL cholesterol, 2.3+/-0.7 mmol/L), and 28 were healthy (controls; LDL cholesterol, 2.5+/-0.8 mmol/L). High-risk children had significantly increased aIMTs and cIMTs (both P
ISSN:0009-7322
1524-4539
DOI:10.1161/hc4901.100522