Molecular characterisation of emergent multiresistant Salmonella enterica serotype [4,5,12:i:−] organisms causing human salmonellosis

Abstract Salmonella multidrug-resistant clinical organisms identified as serotype [4,5,12:i:−] were typed using selected genetic procedures and compared with typhimurium organisms collected in the same Spanish region. Results showed a low genetic heterogeneity among [4,5,12:i:−] organisms, which gen...

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Bibliographic Details
Published in:FEMS microbiology letters 2000-09, Vol.190 (2), p.341-347
Main Authors: Guerra, Beatriz, Laconcha, Idoia, Soto, Sara M., González-Hevia, M.Ángeles, Mendoza, M.Carmen
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antimicrobial resistance
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacterial Typing Techniques
Bacteriology
Biological and medical sciences
Drug Resistance, Microbial
Drug Resistance, Multiple
Electrophoresis, Gel, Pulsed-Field
Epidemiology
Fundamental and applied biological sciences. Psychology
Genetic relationship
Heterogeneity
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Microbiology
Multidrug resistance
Organisms
Plasmid
Plasmids
Plasmids - genetics
Polymerase Chain Reaction
Polymerase chain reaction typing
Pulsed‐field gel electrophoresis
Random Amplified Polymorphic DNA Technique
Ribotyping
Salmonella
Salmonella [4,5,12:i:−]
Salmonella enterica - classification
Salmonella enterica - drug effects
Salmonella enterica - genetics
Salmonella enterica - pathogenicity
Salmonella Infections - microbiology
Salmonella typhimurium - classification
Salmonella typhimurium - genetics
Salmonellosis
Serotyping
Virulence
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Summary:Abstract Salmonella multidrug-resistant clinical organisms identified as serotype [4,5,12:i:−] were typed using selected genetic procedures and compared with typhimurium organisms collected in the same Spanish region. Results showed a low genetic heterogeneity among [4,5,12:i:−] organisms, which generated identical ribotypes and similar but not identical XbaI PFGE, RAPD, and plasmid profiles. Multidrug resistance could be eliminated by curing and seems to be mediated by 140-kb (spvC+) and 120-kb (spvC−) non-self-transferable plasmids. The [4,5,12:i:−] organisms fall into a single genetic lineage, which emerged in 1997 and presents a different degree of genetic relationship with typhimurium lineages.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2000.tb09309.x