Complete regression of colonic adenomas after treatment with sulindac in Gardner's syndrome: a 4-year follow-up

A 22-year-old woman with Gardner's syndrome in whom long-term sulindac therapy, without surgical treatment, was effective in inducing complete regression of colonic adenomas is reported. One hundred milligrams of sulindac was administered twice daily after endoscopic polypectomy. Follow-up colo...

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Bibliographic Details
Published in:Journal of gastroenterology 2001-11, Vol.36 (11), p.778-782
Main Authors: Okai, T, Yamaguchi, Y, Sakai, J, Ohtsubo, K, Mouri, H, Sawabu, N
Format: Article
Language:English
Subjects:
Adenoma - drug therapy
Adenoma - pathology
Adult
Antineoplastic Agents - therapeutic use
Colonic Neoplasms - drug therapy
Colonic Neoplasms - pathology
Female
Follow-Up Studies
Gardner Syndrome - diagnostic imaging
Gardner Syndrome - drug therapy
Gardner Syndrome - pathology
Humans
Radiography
Remission Induction
Skull - diagnostic imaging
Sulindac - therapeutic use
Time Factors
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Summary:A 22-year-old woman with Gardner's syndrome in whom long-term sulindac therapy, without surgical treatment, was effective in inducing complete regression of colonic adenomas is reported. One hundred milligrams of sulindac was administered twice daily after endoscopic polypectomy. Follow-up colonoscopy 6 months later revealed an encouraging regression of colonic adenomas. The tumors had disappeared after 40 months of sulindac treatment. A sustained effect was identified even after 51 months. Ten milligrams of famotidine was coadministered to prevent side effects of sulindac. Although the effect of sulindac on colorectal adenomas may be transient, this therapy may be useful for postponing prophylactic colectomy, especially for the sparse type of familial adenomatous polyposis.
ISSN:0944-1174
1435-5922
DOI:10.1007/s005350170021