Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population

We investigated the effect of the GSTM1 and GSTT1 null genotypes, and GSTP1 313 A/G polymorphism on bladder cancer susceptibility in a case control study of 121 bladder cancer patients, and 121 age- and sex-matched controls of the Turkish population. The adjusted odds ratio for age, sex, and smoking...

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Bibliographic Details
Published in:Archives of toxicology 2001-10, Vol.75 (8), p.459-464
Main Authors: TÖRÜNER, Gökce A, AKYERLI, Cemaliye, UCAR, Ahmet, AKI, Tuncay, ATSU, Necmettin, ÖZEN, Haluk, TEZ, Mesut, CETINKAYA, Mesut, ÖZCELIK, Tayfun
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bladder cancer
Confidence intervals
Female
Genes
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Glutathione S-Transferase pi
Glutathione Transferase - genetics
Health risk assessment
Humans
Isoenzymes - genetics
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Polymerase Chain Reaction
Polymorphism, Genetic
Risk Factors
Smoking
Smoking - adverse effects
Tumors of the urinary system
Turkey - epidemiology
Urinary Bladder Neoplasms - epidemiology
Urinary Bladder Neoplasms - genetics
Urinary tract. Prostate gland
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Summary:We investigated the effect of the GSTM1 and GSTT1 null genotypes, and GSTP1 313 A/G polymorphism on bladder cancer susceptibility in a case control study of 121 bladder cancer patients, and 121 age- and sex-matched controls of the Turkish population. The adjusted odds ratio for age, sex, and smoking status is 1.94 [95% confidence intervals (CI) 1.15-3.26] for the GSTM1 null genotype, and 1.75 (95% CT 1.03-2.99) for the GSTP1 313 A/G or G/G genotypes. GSTT1 was shown not to be associated with bladder cancer. Combination of the two high-risk genotypes. GSTM1 null and GSTP1 313 A/G or G/G, revealed that the risk increases to 3.91-fold (95% CI 1.88-8.13) compared with the combination of the low-risk genotypes of these loci. In individuals with the combined risk factors of cigarette smoking and the GSTM1 null genotype, the risk of bladder cancer is 2.81 times (95% CI 1.23-6.35) that of persons who both carry the GSTM1-present genotype and do not smoke. Similarly, the risk is 2.38-fold (95% CI 1.12-4.95) for the combined GSTP1 313 A/G and G/ G genotypes and smoking. These findings support the role for the GSTM1 null and the GSTP1 313 AG or GG genotypes in the development of bladder cancer. Furthermore, gene-gene (GSTM1-GSTP1) and gene-environment (GSTM1-smoking, GSTP1-smoking) interactions increase this risk substantially.
ISSN:0340-5761
1432-0738
DOI:10.1007/s002040100268