β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

Type 1 diabetes results from autoimmune destruction of insulin-producing pancreatic β cells. The 60 kDa heat-shock protein (hsp60) is one of the known target self antigens. An immunomodulatory peptide from hsp60, p277, arrested β-cell destruction and maintained insulin production in newly diabetic N...

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Bibliographic Details
Published in:The Lancet (British edition) 2001-11, Vol.358 (9295), p.1749-1753
Main Authors: Raz, Itamar, Elias, Dana, Avron, Ann, Tamir, Merana, Metzger, Muriel, Cohen, Irun R
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
C-Peptide - biosynthesis
Chaperonin 60
Diabetes
Diabetes Mellitus, Type 1 - drug therapy
Diabetes. Impaired glucose tolerance
Double-Blind Method
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Heat-Shock Proteins - therapeutic use
Humans
Hypoglycemic Agents - therapeutic use
Insulin
Insulin - administration & dosage
Insulin - metabolism
Insulin Secretion
Interleukins - biosynthesis
Islets of Langerhans - drug effects
Islets of Langerhans - metabolism
Male
Medical sciences
Pancreas
Peptide Fragments - therapeutic use
Peptides
Proteins
Treatment Outcome
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Summary:Type 1 diabetes results from autoimmune destruction of insulin-producing pancreatic β cells. The 60 kDa heat-shock protein (hsp60) is one of the known target self antigens. An immunomodulatory peptide from hsp60, p277, arrested β-cell destruction and maintained insulin production in newly diabetic NOD mice. We did a randomised, double-blind, phase II study of peptide treatment in patients with newly diagnosed (
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(01)06801-5