Effect of paternal age on human sperm chromosomes

Objective: To investigate whether increased age alters the frequency and type of chromosomal anomalies in human spermatozoa. Design: Semen specimens were collected from donors via masturbation; cytogenetic studies were performed on sperm chromosomes after heterologous (human-hamster) in vitro fertil...

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Bibliographic Details
Published in:Fertility and sterility 2001-12, Vol.76 (6), p.1119-1123
Main Authors: Sartorelli, Elza Maria Prestes, Mazzucatto, Luiz Fernando, de Pina-Neto, João Monteiro
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Animals
Biological and medical sciences
chromosomal aberrations
Chromosome Aberrations
Cricetinae
Cytogenetics
Female
Fundamental and applied biological sciences. Psychology
human spermatozoa
Humans
Karyotyping
Male
Mammalian male genital system
Middle Aged
Morphology. Physiology
Paternal Age
Semen - cytology
Semen - physiology
Sperm-Ovum Interactions - physiology
Spermatozoa - cytology
Spermatozoa - physiology
Spermatozoa - ultrastructure
Vertebrates: reproduction
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Summary:Objective: To investigate whether increased age alters the frequency and type of chromosomal anomalies in human spermatozoa. Design: Semen specimens were collected from donors via masturbation; cytogenetic studies were performed on sperm chromosomes after heterologous (human-hamster) in vitro fertilization. Setting: Cytogenetics Laboratory, Genetics Department, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil. Patients(s): Seven men ages 59–74 (older group) and five men ages 23–39 (control group). Main Outcome Measure(s): Frequency and types of chromosomal anomalies in older and control group donors. Result(s): The frequency of numerical and structural aberrations (acentric fragments and complex radial figures) was significantly greater in chromosomes of older donors when compared with those of the control group. Conclusion(s): The higher frequency of sperm chromosome aberrations in older men was mainly a result of increased nondisjunction, acentric fragments, and complex radial figures.
ISSN:0015-0282
1556-5653
DOI:10.1016/S0015-0282(01)02894-1