Vasovagal susceptibility to nitrate or isoproterenol head-up tilt

We assessed sympathovagal balance and baroreflex sensitivity in 80 subjects with recurrent syncope, randomly assigned to head-up tilt with either nitrate or isoproterenol. A vagal predominance in nitrate susceptible individuals compared with an increased sympathetic balance at rest in sioproterenol...

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Bibliographic Details
Published in:The American journal of cardiology 2001-12, Vol.88 (11), p.1326-1330
Main Authors: Niño, Juanita, Villar, Juan Carlos, Tahvanainen, Kari U.O, Kähönen, Mika, Kuusela, Tom A, Morillo, Carlos A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Autonomic Nervous System - drug effects
Autonomic Nervous System - physiopathology
Cardiology
Clinical trials
Cross-Over Studies
Disease Susceptibility
Drug therapy
Female
Heart Rate - drug effects
Humans
Isoproterenol
Isosorbide Dinitrate
Male
Middle Aged
Nitroglycerin
Posture
Sympathomimetics
Syncope, Vasovagal - etiology
Syncope, Vasovagal - physiopathology
Tilt-Table Test
Vasodilator Agents
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Summary:We assessed sympathovagal balance and baroreflex sensitivity in 80 subjects with recurrent syncope, randomly assigned to head-up tilt with either nitrate or isoproterenol. A vagal predominance in nitrate susceptible individuals compared with an increased sympathetic balance at rest in sioproterenol head-up tilt induced neurocardiogenic syncope was observed.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(01)02102-6