Whole brain quantitative CBF, CBV, and MTT measurements using MRI bolus tracking: Implementation and application to data acquired from hyperacute stroke patients

A robust whole brain magnetic resonance (MR) bolus tracking technique based on indicator dilution theory, which could quantitatively calculate cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) on a regional basis, was developed and tested. T2*‐weighted gradient‐echo...

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Published in:Journal of magnetic resonance imaging 2000-09, Vol.12 (3), p.400-410
Main Authors: Smith, Anne M., Grandin, Cécile B., Duprez, Thierry, Mataigne, Frédéric, Cosnard, Guy
Format: Article
Language:English
Subjects:
Blood Flow Velocity
Blood Volume Determination
bolus tracking
Brain - blood supply
Brain - pathology
Brain Mapping - methods
Cerebrovascular Circulation
Diffusion
Gadolinium DTPA
Gd-DTPA
gradient-echo EPI
Humans
Image Enhancement - methods
Infarction, Anterior Cerebral Artery - diagnosis
Magnetic Resonance Imaging - methods
Models, Theoretical
Observer Variation
Predictive Value of Tests
quantitative cerebral perfusion
Regression Analysis
Retrospective Studies
Sensitivity and Specificity
Stroke - diagnosis
Stroke - physiopathology
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Summary:A robust whole brain magnetic resonance (MR) bolus tracking technique based on indicator dilution theory, which could quantitatively calculate cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) on a regional basis, was developed and tested. T2*‐weighted gradient‐echo echoplanar imaging (EPI) volumes were acquired on 40 hyperacute stroke patients after gadolinium diethylene triamine pentaacetic acid (Gd‐DTPA) bolus injection. The thalamus, white matter (WM), infarcted area, penumbra, and mirror infarcted and penumbra regions were analyzed. The calculation of the arterial input function (AIF) needed for absolute quantification of CBF, CBV, and MTT was shown to be user independent. The CBF values (ml/min/100 g units) and CBV values (% units, in parentheses) for the thalamus, WM, infarct, mirror infarct, penumbra, and mirror penumbra (averaged over all patients) were 69.8 ± 22.2 (9.0 ± 3.0 SD); 28.1 ± 6.9 (3.9 ± 1.2); 34.4 ± 22.4 (7.1 ± 2.7); 60.3 ± 20.7 (8.2 ± 2.3); 50.2 ± 17.5 (10.4 ± 2.4); and 64.2 ± 17.0 (9.5 ± 2.3), respectively, and the corresponding MTT values (in seconds) were 8.0 ± 2.1; 8.6 ± 3.0; 16.1 ± 8.9; 8.6 ± 2.9; 13.3 ± 3.5; and 9.4 ± 3.2. The infarct and penumbra CBV values were not significantly different from their corresponding mirror values, whereas the CBF and MTT values were (P < 0.01). Quantitative measurements of CBF, CBV, and MTT were calculated on a regional basis on data acquired from hyperacute stroke patients, and the CBF and MTT values showed greater sensitivity to areas with perfusion defects than the CBV values. J. Magn. Reson. Imaging 2000;12:400–410. © 2000 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/1522-2586(200009)12:3<400::AID-JMRI5>3.0.CO;2-C