Heptaibin, a Novel Antifungal Peptaibol Antibiotic from Emericellopsis sp. BAUA8289

In the course of our antifungal screening program, a novel antifungal substance, heptaibin (1) was isolated from the culture of Emericellopsis sp. BAUA8289 together with emerimicin IV, a peptaibol antibiotic. The structure of 1 was determined by spectroscopic studies. Compound 1 was an analog of eme...

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Bibliographic Details
Published in:Journal of antibiotics 2000/07/25, Vol.53(7), pp.728-732
Main Authors: ISHIYAMA, DAISUKE, SATOU, TSUTOMU, SENDA, HISATO, FUJIMAKI, TSUKASA, HONDA, REIKO, KANAZAWA, SUSUMU
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Anti-Bacterial Agents - chemistry
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Applied microbiology
Bacteria - drug effects
Biological and medical sciences
Emericellopsis
Fermentation
Fundamental and applied biological sciences. Psychology
Fungi - metabolism
Heptaibin
Magnetic Resonance Spectroscopy
Medical sciences
Microbial Sensitivity Tests
Microbiology
Molecular Sequence Data
Molecular Structure
Oligopeptides - chemistry
Oligopeptides - isolation & purification
Oligopeptides - pharmacology
Peptaibols
Peptides
Pharmacology. Drug treatments
Spectrometry, Mass, Fast Atom Bombardment
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Summary:In the course of our antifungal screening program, a novel antifungal substance, heptaibin (1) was isolated from the culture of Emericellopsis sp. BAUA8289 together with emerimicin IV, a peptaibol antibiotic. The structure of 1 was determined by spectroscopic studies. Compound 1 was an analog of emerimicin IV, in which the isovaline residue is replaced with an alpha -amino-isobutyric acid. In this paper, we report the fermentation, isolation, structure determination and biological activities of 1. Heptaibin is produced by Emericellopsis sp. BAUA8289, a fungus isolated from the root of a rice plant growing in Akita, Japan.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.53.728