Magnetoencephalographic fields from patients with spontaneous and induced migraine aura

We investigate and characterize the magnetoencephalographic waveforms from patients during spontaneous and visually induced migraine aura. Direct current neuromagnetic fields were measured during spontaneous onset of migraine auras in 4 migraine patients, and compared with recordings from 8 migraine...

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Bibliographic Details
Published in:Annals of neurology 2001-11, Vol.50 (5), p.582-587
Main Authors: Bowyer, Susan M., Aurora, Sheena K., Moran, John E., Tepley, Norman, Welch, K. M. A.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain Mapping
Cortical Spreading Depression
Female
Humans
Magnetic Resonance Imaging
Magnetoencephalography
Male
Medical sciences
Middle Aged
Migraine with Aura - diagnosis
Migraine with Aura - physiopathology
Neurology
Occipital Lobe - physiopathology
Photic Stimulation
Vascular diseases and vascular malformations of the nervous system
Visual Cortex - physiopathology
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Description
Summary:We investigate and characterize the magnetoencephalographic waveforms from patients during spontaneous and visually induced migraine aura. Direct current neuromagnetic fields were measured during spontaneous onset of migraine auras in 4 migraine patients, and compared with recordings from 8 migraine‐with‐aura patients and 6 normal controls during visual stimulation of the occipital cortex. Complex direct current magnetoencephalographic shifts, similar in waveform, were observed in spontaneous and visually induced migraine patients, but not in controls. Two‐dimensional inverse imaging showed multiple cortical areas activated in spontaneous and visually induced migraine aura patients. In normal subjects, activation was only observed in the primary visual cortex. Results support a spreading, depression‐like neuroelectric event occurring during migraine aura that can arise spontaneously or be visually triggered in widespread regions of hyperexcitable occipital cortex.
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.1293