Renal Doppler sonographic and histologic findings in post‐transplant primary cytomegalovirus disease

Cytomegalovirus (CMV) infections frequently develop in renal transplant patients. The transplanted kidney may be not only the source of infection but also the target for it. We report a case of primary CMV infection in a seronegative patient who received a graft from a seropositive cadaveric donor....

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Bibliographic Details
Published in:Journal of clinical ultrasound 2000-10, Vol.28 (8), p.430-434
Main Authors: Salgado, Octavio J., Henríquez, Carlos, Rosales, Beatriz, Martín, María G., García, Rafael, Rodríguez‐Iturbe, Bernardo
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy, Needle
CMV infection
Cytomegalovirus Infections - diagnostic imaging
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - etiology
Cytomegalovirus Infections - pathology
Doppler ultrasonography
Follow-Up Studies
Ganciclovir - administration & dosage
Graft Survival
Human viral diseases
Humans
Infectious diseases
Kidney Failure, Chronic - surgery
Kidney Transplantation - adverse effects
Kidney Transplantation - methods
Male
Medical sciences
Postoperative Complications - diagnostic imaging
Postoperative Complications - etiology
Postoperative Complications - pathology
renal graft
Treatment Outcome
Ultrasonography, Doppler
Viral diseases
Viral diseases of the genital and urinary system
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Summary:Cytomegalovirus (CMV) infections frequently develop in renal transplant patients. The transplanted kidney may be not only the source of infection but also the target for it. We report a case of primary CMV infection in a seronegative patient who received a graft from a seropositive cadaveric donor. The onset of CMV was clinically apparent on post‐transplant day 22. Interestingly, soon after transplantation, the patient developed a long‐lasting graft dysfunction episode for which diffuse endothelial‐cell swelling was the most relevant finding at biopsy. On sonography, renal graft vascular impedance deteriorated and improved repeatedly during the follow‐up period. We postulate that the patient had CMV‐induced immunogenic‐mediated endothelial‐cell injury. © 2000 John Wiley & Sons, Inc. J Clin Ultrasound 28:430–434, 2000.
ISSN:0091-2751
1097-0096
DOI:10.1002/1097-0096(200010)28:8<430::AID-JCU9>3.0.CO;2-Y