Risk Factors for Recurrent Urinary Tract Infection in Young Women

To define host factors associated with an increased risk of recurrent urinary tract infection (RUTI), a case-control study was conducted in 2 populations: university women and health maintenance organization enrollees. Case patients were 229 women 18–30 years old with RUTIs; control subjects were 25...

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Bibliographic Details
Published in:The Journal of infectious diseases 2000-10, Vol.182 (4), p.1177-1182
Main Authors: Scholes, Delia, Hooton, Thomas M., Roberts, Pacita L., Stapleton, Ann E., Gupta, Kalpana, Stamm, Walter E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Bacterial diseases
Bacterial diseases of the urinary system
Biological and medical sciences
Case-Control Studies
Community Health Services
Continental Population Groups
Contraceptive Agents
Ethnic Groups
Female
Health Maintenance Organizations
Human bacterial diseases
Human sexual behavior
Humans
Infections
Infectious diseases
Major Articles
Medical sciences
Mothers
Odds Ratio
Patient medical history
Predisposing factors
Recurrence
Risk Factors
Sexual Behavior
Spermicides
Universities
Urinary tract infections
Urinary Tract Infections - epidemiology
Urinary Tract Infections - physiopathology
Washington - epidemiology
Women
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Summary:To define host factors associated with an increased risk of recurrent urinary tract infection (RUTI), a case-control study was conducted in 2 populations: university women and health maintenance organization enrollees. Case patients were 229 women 18–30 years old with RUTIs; control subjects were 253 randomly selected women with no RUTI history. In a multivariate model, independent risk factors for RUTI included recent 1-month intercourse frequency (odds ratio [OR], 5.8; 95% confidence interval [CI], 3.1–10.6 for 4–8 episodes), 12-month spermicide use (OR, 1.8; 95% CI, 1.1–2.9), and new sex partner during the past year (OR, 1.9; 95% CI, 1.2–3.2). Two newly identified risk factors were age at first urinary tract infection (UTI) ⩽15 years (OR, 3.9; 95% CI, 1.9–8.0) and UTI history in the mother (OR, 2.3; 95% CI, 1.5–3.7). Blood group and secretor phenotype were not associated with RUTI. In young women, risk factors for sporadic UTI are also risk factors for recurrence. Two predictors suggest that genetic/long-term environmental exposures also predispose to RUTI.
ISSN:0022-1899
1537-6613
DOI:10.1086/315827