SorCS1, a member of the novel sorting receptor family, is localized in somata and dendrites of neurons throughout the murine brain

The expression of the sorCS1 protein in the central nervous system of adult mice was studied by immunohistochemistry. A detailed mapping revealed a distribution of sorCS1 immunoreactivity in a widespread population of neurons throughout the brain. Two different types of cellular localization were ob...

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Bibliographic Details
Published in:Neuroscience letters 2001-11, Vol.313 (1), p.83-87
Main Authors: Hermey, Guido, Riedel, I.Björn, Rezgaoui, Meriem, Westergaard, Uffe B., Schaller, Chica, Hermans-Borgmeyer, I.
Format: Article
Language:English
Subjects:
Animals
Biochemistry and metabolism
Biological and medical sciences
Blotting, Western
Brain - cytology
Cell Membrane - chemistry
Central nervous system
Cytoplasm - chemistry
Dendrites
Dendrites - chemistry
Fundamental and applied biological sciences. Psychology
Fungal Proteins - chemistry
Immunohistochemistry
Membrane Glycoproteins
Membrane Transport Proteins
Mice
Mice, Inbred C57BL
Murine brain
Neurons - chemistry
Neurons - ultrastructure
Protein Structure, Tertiary
Rabbits
Receptors, Cell Surface - analysis
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - immunology
Saccharomyces cerevisiae Proteins
Vertebrates: nervous system and sense organs
Vesicular Transport Proteins
VPS10-domain receptor
Western blot analysis
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Description
Summary:The expression of the sorCS1 protein in the central nervous system of adult mice was studied by immunohistochemistry. A detailed mapping revealed a distribution of sorCS1 immunoreactivity in a widespread population of neurons throughout the brain. Two different types of cellular localization were observed. Many neurons exhibited a punctate cytoplasmic staining which extended into the dendrites, in other neurons sorCS1 immunoreactivity was associated with the plasma membrane. This suggests variable functions for sorCS1 in the neurons of the brain.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(01)02252-2