Neutrophil-endothelial cell interactions during the development of tolerance to ischaemia/reperfusion in isolated cells

Ischaemia/reperfusion (I/R) tolerance refers to the phenomenon by which the inflammation and associated sequelae induced by I/R is ameliorated by an I/R challenge imposed 24 h earlier. The development of I/R tolerance is dependent on the synthesis of new proteins. In vivo and in vitro studies provid...

Full description

Saved in:
Bibliographic Details
Published in:Acta physiologica Scandinavica 2001-09, Vol.173 (1), p.23-33
Main Authors: Cepinskas, G., Rui, T., Kvietys, P. R.
Format: Article
Language:English
Subjects:
Animals
anoxia/reoxygenation
Biological and medical sciences
Blood and lymphatic vessels
cardiac myocytes
Cardiology. Vascular system
Cell Communication - immunology
endothelial cells
Endothelium - cytology
Endothelium, Vascular - cytology
In Vitro Techniques
Ischemic Preconditioning, Myocardial
Medical sciences
Miscellaneous
mutant mice
Myocardial Reperfusion Injury - pathology
Myocardium - cytology
PMN adhesion
PMN transendothelial migration
pre-conditioning
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ischaemia/reperfusion (I/R) tolerance refers to the phenomenon by which the inflammation and associated sequelae induced by I/R is ameliorated by an I/R challenge imposed 24 h earlier. The development of I/R tolerance is dependent on the synthesis of new proteins. In vivo and in vitro studies provide support for nitric oxide synthase (NOS), antioxidant enzymes, and heat shock proteins (HSPs) as the effector proteins. Activation of the nuclear transcription factor, NFκB, appears to be a prerequisite for the development of I/R tolerance. In vitro approaches using anoxia/reoxygenation (A/R) to mimic I/R have provided insights into the complexity of the development of I/R tolerance, i.e. different cells may use different signalling pathways to develop A/R tolerance and influence the responses of adjacent cells during the process. The use of cells from genetically altered mice is expediting attempts to unravel specific mechanisms involved in the development of A/R tolerance.
ISSN:0001-6772
1365-201X
DOI:10.1046/j.1365-201X.2001.00881.x