Nucleic acid vaccines: research tool or commercial reality

Polynucleotide immunization has captured the imagination of numerous researchers and commercial companies around the world as a novel approach for inducing immunity in animals. Clearly, the ‘proof-of-principle’ has been demonstrated both in rodents and various animal species. However, to date, no co...

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Bibliographic Details
Published in:Veterinary Immunology and Immunopathology 2000-08, Vol.76 (1), p.1-23
Main Authors: Babiuk, Lorne A, Babiuk, Shawn L, Loehr, Bianca I, van Drunnen Littel-van den Hurk, Sylvia
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation
Commerce
Humans
Immunity
polynucleotide immunization
Polynucleotide vaccines
polynucleotides
Vaccines, DNA
Veterinary vaccines
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Summary:Polynucleotide immunization has captured the imagination of numerous researchers and commercial companies around the world as a novel approach for inducing immunity in animals. Clearly, the ‘proof-of-principle’ has been demonstrated both in rodents and various animal species. However, to date, no commercial veterinary vaccine has been developed, or to our knowledge, is in the licensing phase. The present review summarizes the types of pathogens and host species for which polynucleotide immunization has been tried. We have tried to identify possible barriers to commercialization of this technology and areas that need attention if this promising technology is ever to become a reality in the commercial arena.
ISSN:0165-2427
1873-2534
DOI:10.1016/S0165-2427(00)00198-7