Melanin and virulence in Cryptococcus neoformans

Melanin synthesis has been associated with virulence for the human pathogenic fungus Cryptococcus neoformans. Recent evidence indicates that C. neoformans cells synthesize melanin during infection and that this pigment protects the fungus against immune defense mechanisms.

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Bibliographic Details
Published in:Current Opinion in Microbiology 2000-08, Vol.3 (4), p.354-358
Main Authors: Casadevall, Arturo, Rosas, Angel L, Nosanchuk, Joshua D
Format: Article
Language:English
Subjects:
Animals
Catecholamine
Cryptococcosis - immunology
Cryptococcosis - microbiology
Cryptococcus neoformans
Cryptococcus neoformans - metabolism
Cryptococcus neoformans - pathogenicity
Cryptococcus neoforms
Fungi
Humans
Infection
Melanin
Melanins - metabolism
Mice
Pathogenesis
Pathogenicity
Pigment
Virulence
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Description
Summary:Melanin synthesis has been associated with virulence for the human pathogenic fungus Cryptococcus neoformans. Recent evidence indicates that C. neoformans cells synthesize melanin during infection and that this pigment protects the fungus against immune defense mechanisms.
ISSN:1369-5274
1879-0364
DOI:10.1016/S1369-5274(00)00103-X