Cerebrovascular Disorders in Children With the Factor V Leiden Mutation

Since 1995, at least 128 children with a cerebrovascular disorder, cerebral palsy, or both and the factor V Leiden mutation have been reported. The majority of these strokes were in the first year of life, many of them in the perinatal period. Two thirds had an additional exogenous risk factor for t...

Full description

Saved in:
Bibliographic Details
Published in:Journal of child neurology 2001-10, Vol.16 (10), p.735-744
Main Authors: Lynch, John Kylan, Nelson, Karin B., Curry, Cynthia J., Grether, Judith K.
Format: Article
Language:English
Subjects:
Cerebral Infarction - diagnosis
Cerebral Infarction - genetics
Cerebral Palsy - diagnosis
Cerebral Palsy - genetics
Cerebrovascular Disorders - diagnosis
Cerebrovascular Disorders - genetics
Factor V - genetics
Female
Follow-Up Studies
Hemiplegia - diagnosis
Hemiplegia - genetics
Humans
Infant
Infant, Newborn
Male
Mutation - genetics
Neurologic Examination
Pregnancy
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Since 1995, at least 128 children with a cerebrovascular disorder, cerebral palsy, or both and the factor V Leiden mutation have been reported. The majority of these strokes were in the first year of life, many of them in the perinatal period. Two thirds had an additional exogenous risk factor for thrombosis, and 42% had another recognized endogenous prothrombotic risk factor in combination with the mutation. We review the association of the factor V Leiden mutation and a cerebrovascular disorder in children younger than 16 years of age and describe the clinical features of 8 children with cerebral palsy and the Leiden mutation. This mutation should be considered in the evaluation of children with a stroke or its sequelae, including infants with perinatal stroke. (J Child Neurol 2001;16:735-744).
ISSN:0883-0738
1708-8283
DOI:10.1177/088307380101601006