Moderate Intervention with Carotenoid-Rich Vegetable Products Reduces Lipid Peroxidation in Men

Because of their antioxidant properties, carotenoids may have beneficial effects in preventing cancer and cardiovascular disease. However, in humans consuming carotenoid-rich vegetables, data concerning the antioxidant effects of carotenoids are rather scarce. A human intervention trial was conducte...

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Bibliographic Details
Published in:The Journal of nutrition 2000-09, Vol.130 (9), p.2200-2206
Main Authors: Bub, Achim, Watzl, Bernhard, Delincée, Henry, Adam, Sieghard, Wever, Joachim, Müller, Harald, Rechkemmer, Gerhard, Abrahamse, Leo
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
antioxidant
Antioxidants - metabolism
Ascorbic Acid - blood
Biological and medical sciences
carotenoid
CAROTENOIDE
CAROTENOIDES
CAROTENOIDS
Carotenoids - administration & dosage
Carotenoids - analysis
Carotenoids - blood
Carotenoids - pharmacology
DIET
DIETA
Feeding. Feeding behavior
Food Analysis
Fundamental and applied biological sciences. Psychology
Glutathione - blood
HEALTH PROTECTION
HUMAN NUTRITION
Humans
Intervention
Lipid Peroxidation - drug effects
Lipids
lipoprotein
LIPOPROTEINAS
LIPOPROTEINE
LIPOPROTEINS
Lipoproteins, LDL - analysis
Male
Men
NUTRICION HUMANA
Nutrition
NUTRITION HUMAINE
OXIDACION
OXIDATION
OXYDATION
PRODUCTOS A BASE DE HORTALIZAS
PRODUIT A BASE DE LEGUME
PROTECCION DE LA SALUD
PROTECTION DE LA SANTE
REGIME ALIMENTAIRE
vegetable
VEGETABLE PRODUCTS
Vegetables
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Because of their antioxidant properties, carotenoids may have beneficial effects in preventing cancer and cardiovascular disease. However, in humans consuming carotenoid-rich vegetables, data concerning the antioxidant effects of carotenoids are rather scarce. A human intervention trial was conducted, therefore, to determine whether a moderately increased consumption of carotenoid-rich vegetables would influence the antioxidant status in 23 healthy men. This short-term feeding study lasted 8 wk during which the men consumed a low carotenoid diet. A 2-wk low carotenoid period was followed by daily consumption of 330 mL tomato juice, then by 330 mL carrot juice and then by 10 g of spinach powder, each for 2 wk. Antioxidant status [water-soluble antioxidants in serum, ferric reducing ability of plasma (FRAP) and antioxidant enzyme activities] and lipid peroxidation (plasma malondialdehyde and ex vivo oxidation of LDL) were determined. In a subgroup of 10 men, lipoprotein carotenoids were measured. The consumption of carotenoid-rich vegetables significantly increased selected carotenoids in lipoproteins but had only minor effects on their relative distribution pattern. Tomato juice consumption reduced plasma thiobarbituric acid reactive substances (TBARS) by 12% (P < 0.05) and lipoprotein oxidizability in terms of an increased lag time (18%, P < 0.05). Carrot juice and spinach powder had no effect on lipid peroxidation. Water-soluble antioxidants, FRAP, glutathione peroxidase and reductase activities did not change during any study period. In evaluating the low carotenoid diet, we conclude that the additional consumption of carotenoid-rich vegetable products enhanced lipoprotein carotenoid concentrations, but only tomato juice reduced LDL oxidation in healthy men. J. Nutr. 130: 2200–2206, 2000.
ISSN:0022-3166
1541-6100
DOI:10.1093/jn/130.9.2200