Angiotensin I converting enzyme polymorphism in humans with age-associated memory impairment: relationship with cognitive performance

We compared the distribution of an insertion (I)/deletion (D) polymorphism coding for the angiotensin I converting enzyme (ACE) gene in 100 subjects fulfilling NIMH criteria for Age-associated memory impairment (AAMI) and 124 controls. We found significantly reduced prevalences of the ACE I/I genoty...

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Bibliographic Details
Published in:Neuroscience letters 2000-09, Vol.290 (3), p.177-180
Main Authors: Bartrés-Faz, David, Junqué, Carme, Clemente, Imma C, López-Alomar, Antoni, Valveny, Neus, López-Guillén, Anselm, López, Teresa, Cubells, M a Jesús, Moral, Pedro
Format: Article
Language:English
Subjects:
ACE
Age Factors
Age-associated memory impairment
Aged
Aging - physiology
Alleles
angiotensin I-converting enzyme
Behavioral psychophysiology
Biological and medical sciences
Cognition - physiology
Elder, Memory
Fundamental and applied biological sciences. Psychology
Genotype
Humans
Memory Disorders - genetics
Memory Disorders - physiopathology
Memory Disorders - psychology
Middle Aged
Miscellaneous
Neuropsychological Tests
Neuropsychology
Peptidyl-Dipeptidase A - genetics
Polymorphism
Polymorphism, Genetic - genetics
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychomotor Performance - physiology
Risk Factors
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Summary:We compared the distribution of an insertion (I)/deletion (D) polymorphism coding for the angiotensin I converting enzyme (ACE) gene in 100 subjects fulfilling NIMH criteria for Age-associated memory impairment (AAMI) and 124 controls. We found significantly reduced prevalences of the ACE I/I genotype together with increases of the ACE D allele in the AAMI group. We further compared the neuropsychological performance of the AAMI group according to their ACE genotype. Those AAMI subjects presenting the ACE I/I genotype exhibited better performance on a measure of frontal lobe function. Our results suggest that the lack of the ACE I/I genotype and the presence of the ACE D allele are associated with memory impairment in the elderly.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(00)01349-5