The value of thyroid transcription factor-1 in cytologic preparations as a marker for metastatic adenocarcinoma of lung origin

In tissue sections, thyroid transcription factor-1 (TTF-1) is a sensitive marker for adenocarcinomas of lung and thyroid origin. This immunohistochemical study evaluates the effectiveness of TTF-1 as a marker for pulmonary adenocarcinomas in paraffin sections of cell block preparations derived from...

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Bibliographic Details
Published in:American journal of clinical pathology 2001-10, Vol.116 (4), p.483-488
Main Authors: HECHT, Jonathan L, PINKUS, Jack L, WEINSTEIN, Lisa J, PINKUS, Geraldine S
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemistry
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Biological and medical sciences
Biomarkers, Tumor - analysis
Biopsy, Needle
Carcinoma, Neuroendocrine - chemistry
Carcinoma, Squamous Cell - chemistry
Diagnosis, Differential
Humans
Immunohistochemistry
Lung Neoplasms - chemistry
Lung Neoplasms - pathology
Medical sciences
Mesothelioma - chemistry
Mesothelioma - pathology
Neoplasm Metastasis
Nuclear Proteins - analysis
Pneumology
Sensitivity and Specificity
Thyroid Nuclear Factor 1
Transcription Factors - analysis
Tumors of the respiratory system and mediastinum
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Summary:In tissue sections, thyroid transcription factor-1 (TTF-1) is a sensitive marker for adenocarcinomas of lung and thyroid origin. This immunohistochemical study evaluates the effectiveness of TTF-1 as a marker for pulmonary adenocarcinomas in paraffin sections of cell block preparations derived from effusion and fine-needle aspiration specimens. We evaluated 122 cell blocks including 8 primary and 39 metastatic pulmonary adenocarcinomas, 11 pulmonary neoplasms of other types, 50 specimens with nonpulmonary metastatic tumors, and 14 mesotheliomas. TTF-1 was reactive in 42 (89%) of 47 pulmonary adenocarcinomas. Only 1 of 4 pulmonary small cell/neuroendocrine tumors was TTF-1 positive, while 1 of 7 squamous cell carcinomas was weakly reactive. Of 50 metastatic tumors of nonpulmonary origin, focal weak reactivity was noted only for 1 metastatic ovarian carcinoma. All mesotheliomas were nonreactive. In cytologic preparations, TTF-1 is a highly selective marker for pulmonary adenocarcinoma and also can have a role in the distinction between pulmonary adenocarcinoma and mesothelioma.
ISSN:0002-9173
1943-7722
DOI:10.1309/NL4Y-FHG8-2XBC-F9XH