Leiden mutation (as genetic) and environmental (retinoids) sequences in the acute and chronic inflammatory and premalignant colon disease in human gastrointestinal tract

Background: Tumor, calor, dolor, pallor and functio laesa are together involved in the different acute and chronic inflammatory processes. The processes involved in the inflammation are determined by differently acquired and hereditary factors. Recently the presence of a new genetic marker (Leiden p...

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Bibliographic Details
Published in:Journal of physiology, Paris Paris, 2001, Vol.95 (1), p.489-494
Main Authors: Mózsik, Gyula, Nagy, Zsuzsanna, Nagy, Agnes, Rumi, György, Karádi, Oszkár, Czimmer, József, Matus, Zoltán, Tóth, Gyula, Pár, Alajos
Format: Article
Language:English
Subjects:
Activated protein-C (APC)
Acute and chronic inflammation in GI tract
Acute Disease
Adult
Aged
Carotenoids
Chronic Disease
Colitis - blood
Colitis - genetics
Colon polyposis without and with malignisation
Colonic Neoplasms - blood
Colonic Neoplasms - genetics
Factor V - analysis
Female
Gene Frequency
Genetic and environmental factors
Helicobacter pylori infection
Hepatitis C infection
Humans
Leiden mutation
Lutein
M. Crohn
Male
Middle Aged
Patients with gastrointestinal diseases
Point Mutation
Precancerous Conditions - blood
Precancerous Conditions - genetics
Reference Values
Retinoids
Retinoids - blood
Ulcerative colitis
Vitamin A
Zeaxantin
α- and β-carotenes
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Summary:Background: Tumor, calor, dolor, pallor and functio laesa are together involved in the different acute and chronic inflammatory processes. The processes involved in the inflammation are determined by differently acquired and hereditary factors. Recently the presence of a new genetic marker (Leiden point mutation) was found in Crohn’s disease and ulcerative colitis. On the other hand, the GI mucosal integrity was proven on gastrointestinal mucosal damage to be produced by different chemicals, xenobiotics, drugs. In human observations, the serum level of retinoids (vitamin A, lutein, zeaxanthin, α-, β-carotene) was proven in patients with chronic gastrointestinal inflammatory bowel disease. The aims of this study were (1) to measure the prevalence of Leiden mutation; (2) to identify the changes in the serum retinoid level in patients with Helicobacter pylori infection of the stomach ( n=24), hepatitis C infection ( n=75), ileitis terminalis (Crohn’s disease; n=49), ulcerative colitis ( n=35), colon polyposis ( n=59) and adenocarcinoma in colon polyps ( n=9), and 57 healthy persons were used in the control group; (3) to compare the directions of the changes in the measured parameters in the acute ( H. pylori and hepatitis C infections), chronic (ileitis terminalis, ulcerative colitis) GI inflammatory diseases and in colon polyposis without and with malignisation. Methods: The Leiden mutation was measured by the method of polimerase chain reaction, the retinoid level in the patient’s serum was measured by high liquid cromathografic method (HPCL). Results: (1) It has been found that the prevalence of Leiden mutation increased significantly in patients with ileitis terminalis ( P
ISSN:0928-4257
1769-7115
DOI:10.1016/S0928-4257(01)00068-7