Attenuated cardiovascular reserve during prolonged submaximal cycle exercise in healthy older subjects

The goal of this study was to determine the effect of age on the hemodynamic response to prolonged submaximal aerobic exercise in healthy volunteers. Reductions in peak work rate, heart rate (HR), and left ventricular (LV) emptying but higher blood pressure (BP) and systemic vascular resistance occu...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2002-10, Vol.40 (7), p.1290-1297
Main Authors: Correia, Luis C.L, Lakatta, Edward G, O’Connor, Frances C, Becker, Lewis C, Clulow, Jon, Townsend, Susan, Gerstenblith, Gary, Fleg, Jerome L
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Aged, 80 and over
Aging - physiology
Biological and medical sciences
Blood pressure
Cameras
Cardiac Volume - physiology
Cardiology
Cardiovascular system
Exercise
Exercise Test - methods
Female
Fitness equipment
Heart rate
Heart Rate - physiology
Hemodynamics - physiology
Humans
Investigative techniques of hemodynamics
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Oxygen Consumption - physiology
Radionuclide Ventriculography
Reference Values
Stroke Volume - physiology
Time Factors
Ventricular Function, Left - physiology
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Summary:The goal of this study was to determine the effect of age on the hemodynamic response to prolonged submaximal aerobic exercise in healthy volunteers. Reductions in peak work rate, heart rate (HR), and left ventricular (LV) emptying but higher blood pressure (BP) and systemic vascular resistance occur in healthy older versus younger humans during short bursts of graded maximal aerobic exercise. However, the effect of aging on the cardiovascular response to prolonged exercise at submaximal work rates typical of daily aerobic activities remains unknown. We evaluated cardiovascular performance throughout prolonged submaximal upright cycle ergometry in 40 carefully screened healthy untrained volunteers, 8 men and 12 women
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(02)02132-0