The interaction of the polymorphisms in transporter of antigen peptides (TAP) and lymphotoxin α (LT-α) genes and atopic diseases in the Czech population

Background Transporter antigen peptide gene (TAP) products are involved in antigen processing. These genes, inducible by interferon γ, as well as lymphotoxin α (LT‐α), are located in the HLA region. Their involvement in immune response regulation makes them candidate atopy susceptibility genes. Obje...

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Bibliographic Details
Published in:Clinical and experimental allergy 2001-09, Vol.31 (9), p.1418-1423
Main Authors: Izakovičová Hollá, L., Vašků, A., Izakovič, V., Znojil, V.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
asthma
atopy
ATP Binding Cassette Transporter, Subfamily B, Member 2
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - immunology
Case-Control Studies
Codon - genetics
Czech Republic - epidemiology
Female
gene
Gene Frequency
Genetics, Population
Genotype
histocompatibility antigen HLA
Humans
Hypersensitivity, Immediate - genetics
Linkage Disequilibrium - genetics
LT-α
lymphotoxin-^a
Lymphotoxin-alpha - genetics
Major Histocompatibility Complex - genetics
Male
Middle Aged
polymorphism
Polymorphism, Genetic - genetics
Smoking
TAP
TAP protein
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Summary:Background Transporter antigen peptide gene (TAP) products are involved in antigen processing. These genes, inducible by interferon γ, as well as lymphotoxin α (LT‐α), are located in the HLA region. Their involvement in immune response regulation makes them candidate atopy susceptibility genes. Objective This study investigates a possible association between previously identified polymorphisms within the TAP‐1 and LT‐α genes and clinically manifested atopic diseases in the Czech population. Methods Caucasian subjects of Czech nationality (n = 427) were included in our study. We examined 184 healthy controls and 243 patients with histories of atopic asthma, allergic rhinitis and atopic dermatitis or their combinations. We used the amplification refractory mutation system polymerase chain reaction to determine TAP‐1 gene polymorphisms. LT‐α genotypes were determined by PCR and restriction analysis by NcoI. Results No significant differences were found in allele or genotype frequencies of the LT‐α gene, as well as in polymorphisms for Val→Ile at codon 333 and Gly→Asp at codon 637 in the TAP‐1 gene between controls and patients. However, analysis of the concurrence of the double genotypes of the TAP‐1 polymorphism at codon 333 and the LT‐α genes showed differences between controls and atopic patients (P 
ISSN:0954-7894
1365-2222
DOI:10.1046/j.1365-2222.2001.01154.x