Acute effect of nicotine on non-smokers: II. MLRs and 40-Hz responses

This paper is the second in a series of three investigating the role of cholinergic mechanisms in the auditory system by assessing the acute effects of nicotine, an acetylcholinomimetic drug, on aggregate responses within the auditory pathway. In a single-blind procedure, auditory responses were obt...

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Bibliographic Details
Published in:Hearing research 2001-10, Vol.160 (1), p.89-98
Main Authors: Whicker Harkrider, Ashley, Champlin, Craig A
Format: Article
Language:English
Subjects:
40-Hz response
Acoustic Stimulation
Administration, Cutaneous
Adolescent
Adult
Auditory evoked potential
Biological and medical sciences
Cholinergic Agents - administration & dosage
Cholinergic Agents - blood
Cholinergic Agents - pharmacology
Cholinergic receptor
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Evoked Potentials, Auditory - drug effects
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Mesogenous
Middle latency response
Nicotine - administration & dosage
Nicotine - blood
Nicotine - pharmacology
Sex Characteristics
Single-Blind Method
Transdermal nicotine
Vertebrates: nervous system and sense organs
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Summary:This paper is the second in a series of three investigating the role of cholinergic mechanisms in the auditory system by assessing the acute effects of nicotine, an acetylcholinomimetic drug, on aggregate responses within the auditory pathway. In a single-blind procedure, auditory responses were obtained from 20 normal-hearing, non-smokers (10 male) under two conditions (nicotine, placebo). The effects of nicotine on central, mesogenous responses of the auditory system (middle latency and 40-Hz responses) are described in this second paper. Results indicated that transdermal administration of nicotine to non-smokers does significantly affect the central, neural transmission of acoustic information. Na–Pa amplitude and Nb latency of the middle latency response and latency measures of the 40-Hz response were acutely altered by the presence of nicotine.
ISSN:0378-5955
1878-5891
DOI:10.1016/S0378-5955(01)00346-X