Differential effects of carbamazepine on negatively versus positively reinforced responding

To assess its effects on negatively versus positively reinforced operant behavior, carbamazepine (CBZ) or vehicle was acutely administered to rats. Negative reinforcement baselines consisted of a free-operant avoidance task with 5-s shock–shock and 20-s response–shock intervals. Positive reinforceme...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-12, Vol.74 (1), p.221-227
Main Authors: Caruso, Mary, Harvey, Mark T, Roberts, Celeste, Patterson, Tina G, Kennedy, Craig H
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - pharmacology
Anticonvulsants. Antiepileptics. Antiparkinson agents
Antiepileptic
Appetite - drug effects
Biological and medical sciences
Carbamazepine
Carbamazepine - pharmacology
Conditioning, Operant - drug effects
Dose-Response Relationship, Drug
Free-operant avoidance
Male
Medical sciences
Negative reinforcement
Neuropharmacology
Operant behavior
Pharmacology. Drug treatments
Positive reinforcement
Rat
Rats
Rats, Sprague-Dawley
Reinforcement (Psychology)
Variable interval schedule
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Summary:To assess its effects on negatively versus positively reinforced operant behavior, carbamazepine (CBZ) or vehicle was acutely administered to rats. Negative reinforcement baselines consisted of a free-operant avoidance task with 5-s shock–shock and 20-s response–shock intervals. Positive reinforcement baselines consisted of responding for food pellets on a variable interval 30-s schedule. Ascending dose–effect functions were established using CBZ for negatively reinforced responding (vehicle, 25, 50, 100 mg/kg ip) and positively reinforced responding (vehicle, 12.5, 25, 50, 100 mg/kg ip). Negatively reinforced responses and avoided shocks were significantly reduced by CBZ injections at 100 mg/kg. Positively reinforced responses and food pellet deliveries were significantly reduced by CBZ injections at 25, 50, and 100 mg/kg. The results show that CBZ has differential, dose-dependent effects on negatively versus positively reinforced responding.
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(02)00990-5