A child with simple ulcer of the colon effectively treated with the combination of prednisolone, azathioprine, and pentoxifylline

A rare case of simple ulcer of the colon in a 7-year-old girl is reported. Simple ulcer is clinically and pathologically recognized as a serious disease linked to intestinal Behcet's disease. Recently, some immunomodulators, such as thalidomide and antitumor necrosis factor monoclonal antibody,...

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Bibliographic Details
Published in:Journal of gastroenterology 2002-09, Vol.37 (9), p.745-749
Main Authors: Kasahara, Etsuo, Yamagishi, Naoko, Tanaka, Miki, Yashiro, Kurato
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - therapeutic use
Azathioprine - administration & dosage
Azathioprine - therapeutic use
Child
Colonic Diseases - drug therapy
Colonic Diseases - pathology
Drug Therapy, Combination
Enzyme Inhibitors - administration & dosage
Enzyme Inhibitors - therapeutic use
Female
Humans
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - therapeutic use
Pentoxifylline - administration & dosage
Pentoxifylline - therapeutic use
Prednisolone - administration & dosage
Prednisolone - therapeutic use
Ulcer - drug therapy
Ulcer - pathology
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Summary:A rare case of simple ulcer of the colon in a 7-year-old girl is reported. Simple ulcer is clinically and pathologically recognized as a serious disease linked to intestinal Behcet's disease. Recently, some immunomodulators, such as thalidomide and antitumor necrosis factor monoclonal antibody, have been used to treat Behcet's disease, with varying degrees of success. Pentoxifylline (PTX) is also known to inhibit such inflammatory mediators as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6. In this present patient combination treatment with prednisolone, azathioprine, and PTX improved corticosteroid dependence palliatively and prevented further relapse during a follow-up period of more than 12 months, without serious side effects.
ISSN:0944-1174
1435-5922
DOI:10.1007/s005350200122