TLS-CHOP target gene DOL54 expression in liposarcomas and malignant fibrous histiocytomas

Downstream of the gene for the liposarcoma‐associated fusion oncoprotein 54 (DOL54) is a target gene of the myxoid liposarcoma and round cell liposarcoma (M‐LPS/RC‐LPS) oncogene, TLS/FUS‐CHOP. The DOL54 gene product is closely associated with adipogenic differentiation. DOL54 overexpression resulted...

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Bibliographic Details
Published in:Pathology international 2002-08, Vol.52 (8), p.497-500
Main Authors: Domoto, Hideharu, Hosaka, Taisuke, Oikawa, Kosuke, Ohbayashi, Tetsuya, Ishida, Tsuyoshi, Izumi, Miki, Iwaya, Keiichi, Toguchida, Junya, Kuroda, Masahiko, Mukai, Kiyoshi
Format: Article
Language:English
Subjects:
Blotting, Northern
CCAAT-Enhancer-Binding Proteins - biosynthesis
DOL54
Gene Expression Regulation, Neoplastic
Histiocytoma, Benign Fibrous - genetics
Humans
Liposarcoma - genetics
Liposarcoma, Myxoid - genetics
malignant fibrous histiocytoma
myxoid and round cell liposarcoma
Oncogene Proteins, Fusion - biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
RNA-Binding Protein FUS - biosynthesis
TLS-CHOP
Transcription Factor CHOP
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Summary:Downstream of the gene for the liposarcoma‐associated fusion oncoprotein 54 (DOL54) is a target gene of the myxoid liposarcoma and round cell liposarcoma (M‐LPS/RC‐LPS) oncogene, TLS/FUS‐CHOP. The DOL54 gene product is closely associated with adipogenic differentiation. DOL54 overexpression resulted in tumorigenicity when Chinese Hamster Ovary (CHO) cells were injected subcutaneously into nude mice. The biological significance of DOL54 expression for human malignant soft tissue tumors, however, has not yet been investigated. We examined TLS‐CHOP and DOL54 expression in M‐LPS/RC‐LPS, well‐differentiated liposarcoma and malignant fibrous histiocytoma (MFH), a tumor whose cellular origin has not been determined. We observed DOL54 expression in 50% of M‐LPS/RC‐LPS cases (in which TLS‐CHOP was also expressed) and 33% of MFH cases, suggesting that a portion of MFH lesions may either derive from adipocytic precursor cells or have the potential to undergo adipogenic differentiation. In this manner, M‐LPS/RC‐LPS and MFH lesions may share tumorigenic characteristics, resulting from the unscheduled expression of DOL54.
ISSN:1320-5463
1440-1827
DOI:10.1046/j.1440-1827.2002.01391.x